Triisopropyl orthoformate
Triisopropyl orthoformate (CAS 4447-60-3), with the molecular formula CH[OCH(CH3)2]3 and a molecular weight of 190.28 g/mol, is an organic orthoester. It serves as a versatile building block in organic synthesis, commonly employed as a reagent for formylation reactions and the protection of functional groups. Its utility extends to the preparation of various organic compounds and intermediates.
![Triisopropyl orthoformate (CH[OCH(CH3)2]3) — chemical structure, CAS 4447-60-3; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F4447-60-3.png&w=3840&q=75)
Formylation Reagent
Triisopropyl orthoformate is a useful reagent for introducing a formyl group (-CHO) into organic molecules. It is particularly valuable in the synthesis of aldehydes and related compounds.
Protecting Group Chemistry
This orthoester can be used to protect diols and other functionalities during multi-step syntheses. The isopropyl orthoformate group can be readily removed under appropriate conditions.
Synthesis of Heterocycles
It finds application in the construction of various heterocyclic ring systems, acting as a source of a one-carbon unit in cyclization reactions.
Intermediate for Organic Synthesis
As a functionalised building block, Triisopropyl orthoformate is employed in the preparation of a wide array of complex organic molecules and fine chemicals.
| Molecular weight | 190.28 |
|---|---|
| Linear formula | CH[OCH(CH3)2]3 |
| Assay | 97% |
| Boiling point | 65-66 °C/18 mmHg(lit.) |
| Density | 0.854 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.397(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 42 °C / 107.6 °F |
| Transport (UN / ADR) | UN 3272 3 / PGIII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Triisopropyl orthoformate used for?
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Triisopropyl orthoformate (CAS 4447-60-3) is used as a formylation reagent, for protecting functional groups, and as a building block in organic synthesis.
What are the CAS number and formula for Triisopropyl orthoformate?
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The CAS number is 4447-60-3 and the linear formula is CH[OCH(CH3)2]3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Triisopropyl orthoformate with a minimum purity of 97%. We do not represent this product as USP, BP, EP, or any pharmacopoeia grade.
How should Triisopropyl orthoformate be handled safely?
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Triisopropyl orthoformate is a flammable liquid and vapour (H226). It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and ensure adequate ventilation. Avoid ignition sources.
How is Triisopropyl orthoformate packed, shipped, and exported?
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Triisopropyl orthoformate is packed and shipped according to international regulations for hazardous materials, including UN 3272. TSS is a specialist global supplier and exporter.
How can I request a quote or sample for Triisopropyl orthoformate?
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Please contact our sales team via the website to request a quote or a sample of Triisopropyl orthoformate.
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