trans-2-(3-Fluorophenyl)vinylboronic acid
Tech Serve Solutions offers trans-2-(3-Fluorophenyl)vinylboronic acid (CAS: 849062-22-2), a key organoboron compound with the molecular formula C8H8FBO2. This white solid serves as a crucial building block in advanced organic synthesis. Its applications span the preparation of complex pharmaceuticals, including anticonvulsant agents and histone deacetylase inhibitors, as well as its utility in stereoselective cross-coupling reactions like the Suzuki-Miyaura coupling.
- IUPAC
- (E)-2-(3-Fluorophenyl)ethenylboronic acid
- Synonyms
- (E)-2-(3-Fluorophenyl)ethenylboronic acid
Suzuki-Miyaura Coupling
This compound is an effective reactant in palladium-catalyzed Suzuki-Miyaura coupling reactions, enabling the formation of carbon-carbon bonds for creating diverse molecular architectures.
Pharmaceutical Intermediate
It is utilized in the synthesis of various pharmaceutical agents, including anticonvulsants and potential antitumor compounds by acting as a key intermediate in multi-step synthetic pathways.
Stereoselective Synthesis
The boronic acid participates in stereoselective Suzuki cross-coupling reactions to prepare ethyl-substituted conjugated dienoates and dienones, controlling product stereochemistry.
Synthesis of Tetracyclines
It serves as a reactant in the enantioselective and diastereoselective synthesis of tetracyclines, involving metal-catalyzed ring opening and subsequent functionalization steps.
| Molecular weight | 165.96 |
|---|---|
| Empirical formula | C8H8FBO2 |
| Application | Reactant for:• Enantioselective diastereoselective synthesis of tetracyclins via metal-catalyzed ring opening of meso-oxabicyclic alkenes followed by hydrogenation and Friedel-Crafts alkylation1• Palladium-catalyzed Suzuki-Miyaura coupling reactions2• Preparation of anticonvulsant agents3• Preparation of piperazinyl pyrimidylhydroxamic acid deriatives as histone deacetylase inhibitors and antitumor agents4• Preparation of ethyl-substituted conjugated dienoates and dienones by stereoselective Suzuki cross-coupling5 |
| Melting point | 184-186 °C(lit.) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is trans-2-(3-Fluorophenyl)vinylboronic acid used for?
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trans-2-(3-Fluorophenyl)vinylboronic acid is used as a reactant in organic synthesis, particularly for Suzuki-Miyaura coupling reactions, preparation of anticonvulsant agents, histone deacetylase inhibitors, antitumor agents, and in the synthesis of tetracyclines.
What is the CAS number and molecular formula for trans-2-(3-Fluorophenyl)vinylboronic acid?
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The CAS number is 849062-22-2 and the molecular formula is C8H8FBO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a research or technical grade chemical. It is not represented as USP, BP, EP, or for food, drug, or medical use.
What are the safety and handling precautions for trans-2-(3-Fluorophenyl)vinylboronic acid?
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trans-2-(3-Fluorophenyl)vinylboronic acid is classified with a WGK Germany of 3, indicating it is hazardous. Handle with appropriate personal protective equipment in a well-ventilated area. Consult the Safety Data Sheet for detailed hazard information and handling procedures.
How is trans-2-(3-Fluorophenyl)vinylboronic acid packed and shipped?
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Tech Serve Solutions carefully packs and ships chemicals globally, adhering to all relevant regulations for safe transport. Specific packaging details are available upon request.
How can I request a sample or quote for trans-2-(3-Fluorophenyl)vinylboronic acid?
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To request a sample or a quotation, please contact our sales team via the website or direct inquiry. Provide the product name and CAS number (849062-22-2) for prompt service.
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