γ-Thiobutyrolactone
γ-Thiobutyrolactone (CAS: 1003-10-7, C4H6OS) is a sulphur-containing heterocyclic compound with a molecular weight of 102.15 g/mol. This versatile building block is utilised in chemical synthesis, particularly for creating complex organic molecules. Its applications extend to polymer chemistry, where it can function in ring-opening polymerisation termination, and in biochemical studies investigating the metabolism of sulphur compounds.
- IUPAC
- 4-Butyrothiolactone

Polymer Synthesis
γ-Thiobutyrolactone can serve as a terminating agent in the ring-opening polymerisation of lactones, such as ω-pentadecalactone, to produce difunctional polyesters.
Biochemical Research
It has been employed in studies to investigate the metabolic pathways of sulphur-containing heterocyclic compounds by lignin-degrading organisms like <i>Coriolus versicolor</i>.
Organic Synthesis Intermediate
As a heterocyclic building block, it is valuable in the synthesis of diverse organic structures and thiophene derivatives.
| Molecular weight | 102.15 |
|---|---|
| Empirical formula | C4H6OS |
| Assay | 98% |
| Boiling point | 39-40 °C/1 mmHg(lit.) |
| Density | 1.18 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.523(lit.) |
| Solubility | THF: soluble |
| Application | γ-Thiobutyrolactone was used to terminate the ring opening polymerization of ω-pentadecalactone to synthesize difunctional polyesters1. γ-Thiobutyrolactone was used to study the mechanism of metabolism of sulphur containing heterocyclic compounds by lignin-degrading basidiomycete Coriolus versicolor2. |

Hazard statements
- H302Harmful if swallowed
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 86 °C / 186.8 °F |
| Transport (UN / ADR) | UN 3334 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is γ-Thiobutyrolactone used for?
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γ-Thiobutyrolactone is used in chemical synthesis, for example, to terminate ring-opening polymerisation of lactones and in biochemical studies on the metabolism of sulphur-containing heterocyclic compounds.
What are the CAS number and formula for γ-Thiobutyrolactone?
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The CAS number for γ-Thiobutyrolactone is 1003-10-7, and its empirical formula is C4H6OS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies γ-Thiobutyrolactone with an assay of 98%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should γ-Thiobutyrolactone be handled safely?
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γ-Thiobutyrolactone is classified as harmful if swallowed (H302) and requires careful handling. Recommended personal protective equipment includes eyeshields, gloves, and appropriate respiratory protection such as a type ABEK respirator filter or a full-face respirator.
Is γ-Thiobutyrolactone packed, shipped, or exported by TSS?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including γ-Thiobutyrolactone, and adheres to all shipping regulations.
How can I request a sample or quote for γ-Thiobutyrolactone?
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Please contact our sales team directly via the website or email to request a sample or obtain a quotation for γ-Thiobutyrolactone.
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