Tetramethylurea

CAS 632-22-4(CH3)2NCON(CH3)2Chemical Synthesis

Tetramethylurea (CAS 632-22-4), also known as TMU, is an organic compound with the linear formula (CH3)2NCON(CH3)2 and a molecular weight of 116.16 g/mol. This highly polar aprotic solvent is valued for its ability to dissolve a wide range of organic and inorganic compounds. It serves as a versatile reagent and building block in organic synthesis, particularly in reactions requiring high polarity and a non-nucleophilic medium. Its applications span various chemical research and development fields.

IUPAC: 1,1,3,3-Tetramethylurea,TMU
Synonyms: 1,1,3,3-TetramethylureaTMU

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Tetramethylurea ((CH3)2NCON(CH3)2) — chemical structure, CAS 632-22-4; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksCarbonyl CompoundsChemical SynthesisOrganic Building BlocksUreas

01 /Applications

Solvent in Organic Synthesis

Tetramethylurea functions as a high-boiling, polar aprotic solvent, facilitating reactions such as alkylations, acylations, and organometallic transformations. Its strong solvating power can enhance reaction rates and yields in complex synthetic pathways.

Reagent for Chemical Reactions

As a urea derivative, TMU can participate in specific chemical reactions or act as a catalyst or additive to influence reaction selectivity and kinetics. It is commonly employed in the synthesis of heterocyclic compounds and other complex organic molecules.

Laboratory Reagent

Widely used in research laboratories, Tetramethylurea is a valuable reagent for academic and industrial chemists exploring new synthetic methodologies or investigating reaction mechanisms that benefit from its unique solvent properties.

02 /Properties

Molecular weight	116.16
Linear formula	(CH3)2NCON(CH3)2
Assay	99%
Boiling point	177 °C(lit.)62-63 °C/12 mmHg(lit.)
Density	0.968 g/mL at 20 °C(lit.)
Refractive index	n20/D 1.451(lit.)
Melting point	−1 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Danger

Hazard statements

H302Harmful if swallowed
H360D

Precautionary statements

P201Obtain special instructions before use
P308IF exposed or concerned

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	75 °C / 167 °F
Transport (UN / ADR)	UN 1993 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	61-22
Safety statements (S)	53-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

632-22-4

MDL number

MFCD00008319

Beilstein registry

773898

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Tetramethylurea (CAS 632-22-4) used for?

Tetramethylurea is primarily used as a polar aprotic solvent in organic synthesis and as a reagent or building block in various chemical reactions, particularly in research and development settings.

What is the CAS number and chemical formula for Tetramethylurea?

The CAS number for Tetramethylurea is 632-22-4 and its linear formula is (CH3)2NCON(CH3)2.

What grade and purity does Tech Serve Solutions supply for Tetramethylurea?

Tech Serve Solutions supplies Tetramethylurea with an assay of 99%. This product is not represented as USP, BP, EP, or other pharmacopoeia grades.

What are the primary safety concerns when handling Tetramethylurea?

Tetramethylurea is classified as dangerous, with hazards including H302 (Harmful if swallowed) and H360D (May damage the unborn child). Appropriate personal protective equipment, including eye and face protection, gloves, and respiratory protection, must be used. Handle with extreme caution, particularly concerning reproductive toxicity.

Is Tetramethylurea available for export?

Yes, Tech Serve Solutions, a specialist global supplier and exporter, can provide Tetramethylurea. Please contact us for export details and shipping information.

How can I request a sample or quote for Tetramethylurea?

To request a sample or a quote for Tetramethylurea, please visit the Tech Serve Solutions website or contact our sales team directly with your specific requirements.