Tetrabenazine
Tetrabenazine (CAS: 58-46-8), a benzoquinolizine derivative with the formula C19H27NO3, is a bioactive small molecule primarily known for its neurochemical applications. With a molecular weight of 317.42 g/mol, it functions by influencing neurotransmitter levels, particularly dopamine. Tetrabenazine is utilized in research settings for dopamine uptake assays and non-specific binding studies in neuronal cell models.
- IUPAC
- 9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-3-isobutyl-2H-benzo[a]quinolizin-2-one
Dopamine Uptake Assays
Tetrabenazine is employed in research for conducting dopamine uptake assays. These studies are crucial for understanding dopaminergic neurotransmission and the mechanisms of related neurological disorders.
Non-specific Binding Assays
The compound serves as a tool in non-specific binding assays, particularly within postnuclear supernatants derived from cell lines like PC-12 and CV-1, aiding in the characterisation of receptor interactions.
Neuroscience Research
As a dopaminergic agent, Tetrabenazine is valuable in neuroscience research for investigating neurotransmitter systems and their roles in various physiological and pathological processes.
| Molecular weight | 317.42 |
|---|---|
| Empirical formula | C19H27NO3 |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Solubility | DMSO: >10 mg/mLH2O: insoluble |
| Storage temperature | 2-8°C |
| Application | Tetrabenazine has been used for dopamine uptake assays in mouse brain cells1. Tetrabenazine has also been used for non-specific binding assays in postnuclear supernatants derived from PC-12 and CV-1 cells2. |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tetrabenazine used for?
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Tetrabenazine is used in research for dopamine uptake assays and non-specific binding assays in neuronal cell models, contributing to neuroscience and cell biology research.
What are the CAS number and formula for Tetrabenazine?
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The CAS number for Tetrabenazine is 58-46-8, and its empirical formula is C19H27NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tetrabenazine with a purity of ≥98% (HPLC). This product is intended for research and laboratory use; TSS does not represent it as USP, BP, or EP grade.
How should Tetrabenazine be handled and stored?
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Tetrabenazine is classified as harmful if swallowed (H302) and requires handling with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves. It should be stored at 2-8°C.
Is Tetrabenazine a controlled substance?
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The provided data does not indicate that Tetrabenazine is a controlled substance. Please consult relevant local regulations for specific handling requirements.
How is Tetrabenazine shipped?
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Tetrabenazine is supplied as a solid and is typically shipped according to standard chemical handling and transportation guidelines. For export inquiries, please contact our sales team.
How can I request a sample or quote for Tetrabenazine?
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To request a sample or a quote for Tetrabenazine, please contact the Tech Serve Solutions sales department via our website or direct email.
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