tert-Butyl phenyl carbonate
Tert-Butyl phenyl carbonate (CAS 6627-89-0) is an organic compound with the linear formula (CH3)3COCOOC6H5 and a molecular weight of 194.23 g/mol. This carbonate serves as a valuable reagent in organic synthesis, particularly for introducing the tert-butoxycarbonyl (Boc) protecting group. Its applications span diverse chemical transformations, aiding researchers in pharmaceutical and materials science.
Protecting Group Chemistry
Tert-Butyl phenyl carbonate is employed as a reagent for the mono-Boc protection of α,ω-diamines. This selective protection is crucial in multi-step organic synthesis to prevent unwanted side reactions.
Determination of Partition Coefficients
This compound has been utilised in the determination of octanol-water partition coefficients. Its application in microemulsion electrokinetic chromatography aids in understanding the lipophilicity of various substances.
Synthesis of Heterocycles
Tert-Butyl phenyl carbonate is a useful intermediate in the synthesis of specific organic molecules, such as 2-nitroindoles. This highlights its role in building complex molecular architectures.
| Molecular weight | 194.23 |
|---|---|
| Linear formula | (CH3)3COCOOC6H5 |
| Assay | ≥97.0% (GC) |
| Boiling point | 83 °C/0.6 mmHg(lit.) |
| Density | 1.05 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.480 |
| Application | tert-Butyl phenyl carbonate was used in determination of octanol-water partition coefficients by microemulsion electrokinetic chromatography1. It was also used in the synthesis of 2-nitroindoles2. It was used as reagent for mono-Boc protection of α,ω-diamines3. |
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Flash point | 101 °C / 213.8 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is tert-Butyl phenyl carbonate used for?
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Tert-Butyl phenyl carbonate is used as a reagent for mono-Boc protection of α,ω-diamines, in the determination of octanol-water partition coefficients, and in the synthesis of 2-nitroindoles.
What is the CAS number and formula for tert-Butyl phenyl carbonate?
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The CAS number is 6627-89-0, and the linear formula is (CH3)3COCOOC6H5.
What grade and purity does Tech Serve Solutions supply for tert-Butyl phenyl carbonate?
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Tech Serve Solutions supplies tert-Butyl phenyl carbonate with an assay of ≥97.0% (GC). We do not represent this product as USP, BP, or EP grade.
How should tert-Butyl phenyl carbonate be handled?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves, due to its chemical nature. Refer to the Safety Data Sheet for detailed guidance.
Is tert-Butyl phenyl carbonate a controlled substance?
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Based on the provided data, tert-Butyl phenyl carbonate is not listed as a controlled substance.
How is tert-Butyl phenyl carbonate typically packed and exported?
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This chemical is carefully packed to ensure stability during transit and is available for global export by Tech Serve Solutions.
How can I request a quote or sample of tert-Butyl phenyl carbonate?
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Please contact our sales team through the website or by phone to request a quote or a sample of tert-Butyl phenyl carbonate.
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