Tebbe reagent solution
Tebbe reagent solution (CAS 67719-69-1) is a potent organometallic compound vital for organic synthesis. This solution, typically 0.5 M in toluene, features a titanium-aluminum complex renowned for its exceptional methylenation capabilities. It efficiently converts carbonyl compounds like ketones and aldehydes into olefins, and can transform esters into vinyl ethers. Its utility extends to reactions involving sterically hindered substrates, making it a valuable tool in advanced chemical research and development.
- IUPAC
- Bis(cyclopentadienyl)-μ-chloro(dimethylaluminum)-μ-methylenetitanium
Methylenation of Carbonyl Compounds
Tebbe reagent solution is a highly effective reagent for the conversion of aldehydes and ketones into their corresponding terminal alkenes. This transformation is crucial in the synthesis of various organic molecules.
Olefination Reactions
It serves as a powerful methylenating agent in olefination reactions, enabling the formation of C=C double bonds. This is particularly useful for challenging substrates, including sterically hindered carbonyls.
Ester to Vinyl Ether Conversion
The reagent can facilitate the transformation of esters into vinyl ethers, expanding its synthetic utility beyond simple olefination of aldehydes and ketones.
C-C Bond Formation
As an organometallic reagent, Tebbe reagent solution participates in key C-C bond forming reactions, contributing to the construction of complex organic frameworks in multi-step syntheses.
| Molecular weight | 284.58 |
|---|---|
| Empirical formula | C13H18AlClTi |
| Density | 0.927 g/mL at 25 °C |
| Concentration | 0.5 M in toluene |
| Application | A versatile methylenation reagent for the conversion of ketones and aldehydes to olefins, it offers facile reaction with hindered ketones and allows the conversion of esters to vinyl ethers.1 |
Hazard statements
- H225Highly flammable liquid and vapour
- H304May be fatal if swallowed and enters airways
- H314Causes severe skin burns and eye damage
- H336May cause drowsiness or dizziness
- H361D
- H373May cause damage to organs through prolonged exposure
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 4 °C / 39.2 °F |
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 63-11-34-48/20-65-67 |
| Safety statements (S) | 16-26-36/37/39-45-62 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tebbe reagent solution primarily used for?
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Tebbe reagent solution is primarily used as a versatile methylenation reagent for the conversion of ketones and aldehydes to olefins, and esters to vinyl ethers, especially effective with hindered substrates.
What is the CAS number and formula for Tebbe reagent solution?
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The CAS number for Tebbe reagent solution is 67719-69-1. The empirical formula is C13H18AlClTi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tebbe reagent solution at a concentration of 0.5 M in toluene. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades; it is supplied for research and development purposes.
How should Tebbe reagent solution be handled safely?
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Tebbe reagent solution is a Danger material (GHS02, GHS05, GHS07, GHS08). It is flammable, can cause severe skin burns and eye damage, may be fatal if swallowed and enters airways, and can cause drowsiness or dizziness. Handle with extreme caution using appropriate personal protective equipment including faceshields, gloves, goggles, and a suitable respirator. Store away from ignition sources.
How is Tebbe reagent solution packed and shipped?
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Tebbe reagent solution is supplied in 25mL Sure/Seal reagents bottles and is shipped according to UN 2924 8(3) / PGII regulations, indicating it is a corrosive and flammable liquid, n.o.s.
How can I request a quote or sample?
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To request a quote or sample of Tebbe reagent solution, please contact our sales team through the website or call us directly. Please specify the quantity required and your shipping destination.
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