Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt
Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt (CAS 185332-92-7), with the molecular formula C12H11N2NaO9S and a molecular weight of 382.28 g/mol, is a water-soluble crosslinking agent. It features a maleimide group that reacts with sulfhydryl groups and an N-hydroxysuccinimide (NHS) ester that reacts with primary amines. This bifunctional nature makes it valuable for bioconjugation and chemical synthesis applications.
- IUPAC
- 4-Maleimidobutyric acid sulfo-N-succinimidyl ester sodium salt,N-(γ-Maleimidobutyryloxy)sulfosuccinimide sodium salt,Sulfo-GMBS
- Synonyms
- Sulfo-GMBS4-Maleimidobutyric acid sulfo-N-succinimidyl ester sodium saltN-(γ-Maleimidobutyryloxy)sulfosuccinimide sodium salt
Bioconjugation
This compound enables the covalent linkage of molecules containing primary amines to molecules containing sulfhydryl groups. It is widely used in protein labelling, antibody-drug conjugate preparation, and other biochemical studies requiring stable hetero-bifunctional crosslinking.
Surface Modification
Its reactivity profile allows for the modification of surfaces functionalised with either amine or sulfhydryl groups. This can be applied to immobilise biomolecules onto substrates for biosensor development or diagnostic assays.
Peptide Synthesis
Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt can be employed in solid-phase or solution-phase peptide synthesis to introduce specific crosslinks or functional handles.
Chemical Synthesis
As a bifunctional reagent, it serves as a versatile building block in complex organic synthesis, allowing for the controlled introduction of specific functionalities and linkers.
| Molecular weight | 382.28 |
|---|---|
| Empirical formula | C12H11N2NaO9S |
| Assay | ~90% |
| Storage temperature | −20°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt used for?
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This compound is primarily used as a water-soluble, hetero-bifunctional crosslinking reagent in chemical biology and synthesis. It reacts with both primary amines and sulfhydryl groups, enabling applications such as bioconjugation, protein labelling, and surface modification.
What is the CAS number and formula for Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt?
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The CAS number is 185332-92-7 and the molecular formula is C12H11N2NaO9S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of approximately 90%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling considerations for this product?
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This product is classified as a Warning. It can cause skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves, should be used. Ensure adequate ventilation.
How is this product shipped and exported?
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This chemical is typically stored at -20°C. Tech Serve Solutions is a specialist global supplier and exporter and can arrange for appropriate packaging and shipping methods to meet international regulations and customer requirements.
How can I request a sample or quote?
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To request a sample or a quote for Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt, please visit our website or contact our sales team directly.
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