SR8278
SR8278 (CAS: 1254944-66-5) is a chemical compound with the formula C18H19NO3S2 and a molecular weight of 361.48 g/mol. This substance functions as a rev-erb alpha antagonist. It is primarily utilised in scientific research to investigate the regulation of glucagon secretion in pancreatic alpha and beta cells, contributing to advancements in cell biology and metabolic research.
- IUPAC
- 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
Investigating Glucagon Secretion Regulation
SR8278 serves as a critical tool for researchers studying the intricate mechanisms governing glucagon secretion. Its application in mouse pancreatic alpha and beta cells provides key insights into cellular signalling pathways. This research is vital for understanding metabolic disorders.
Rev-erb Alpha Antagonist Studies
As a specific rev-erb alpha antagonist, SR8278 enables precise investigation into the role of this nuclear receptor in gene regulation. This is particularly relevant for studies in cell biology and neuroscience, exploring downstream effects on cellular functions.
Gene Regulation Research
The compound is employed in research focused on gene regulation and expression. By modulating rev-erb alpha activity, scientists can explore its influence on various cellular processes and gene networks, furthering our understanding of biological systems.
| Molecular weight | 361.48 |
|---|---|
| Empirical formula | C18H19NO3S2 |
| Assay | ≥98% |
| Form | semisolid |
| Colour | white to tan |
| Solubility | DMSO: ≥30 mg/mL |
| Storage temperature | 2-8°C |
| Application | SR8278 was used as rev-erb alpha antagonist to study the regulation of glucagon secretion in mouse pancreatic alpha cells1 and beta cells.2 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SR8278 used for?
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SR8278 is used as a rev-erb alpha antagonist to study the regulation of glucagon secretion in mouse pancreatic alpha and beta cells, and in research related to gene regulation and expression.
What is the CAS number and formula for SR8278?
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The CAS number for SR8278 is 1254944-66-5, and its empirical formula is C18H19NO3S2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies SR8278 with an assay of ≥98%. We do not represent this product as USP, BP, or EP grade.
How should SR8278 be stored and handled?
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SR8278 should be stored at 2-8°C. It is classified under GHS hazard category 3 (WGK Germany), indicating potential environmental hazards. Handle with appropriate laboratory precautions.
How is SR8278 shipped?
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SR8278 is packed and shipped according to standard chemical handling protocols, ensuring product integrity and regulatory compliance for global export.
How can I request a quote or sample?
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To request a quote or sample of SR8278, please contact our sales team via the website or email, providing your specific requirements.
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