Sodium phosphate tribasic dodecahydrate
Sodium phosphate tribasic dodecahydrate (CAS: 10101-89-0), with the formula Na3PO4 · 12H2O and a molecular weight of 380.12 g/mol, is a hydrated inorganic salt. It is commonly employed as a buffering agent in analytical chemistry, particularly in chromatographic methods. Its properties make it suitable for various chemical synthesis and laboratory reagent applications. Tech Serve Solutions supplies this compound with a high assay, ensuring reliability for research and industrial processes.
- IUPAC
- TSP,Trisodium phosphate (tert) dodecahydrate,Trisodium phosphate dodecahydrate
- Synonyms
- Trisodium phosphate dodecahydrateTSPTrisodium phosphate (tert) dodecahydrate

Buffer Preparation for Chromatography
Sodium phosphate tribasic dodecahydrate is used to prepare buffer solutions. For example, it has been utilised in high-performance liquid chromatography (HPLC) for the analysis of pyronaridine in biological samples like human whole blood and plasma.
Chemical Synthesis Reagent
As a versatile inorganic salt, it serves as a reagent in various chemical synthesis pathways. Its specific properties can be leveraged in reactions requiring a source of tribasic phosphate ions or a highly alkaline medium.
Laboratory Reagent
This compound functions as a general laboratory reagent. Its solubility and buffering capacity make it useful in a range of experimental procedures and analytical techniques common in research and development settings.
| Molecular weight | 380.12 |
|---|---|
| Linear formula | Na3PO4 · 12H2O |
| Assay | ≥99.0% |
| Density | 1.62 g/mL at 25 °C |
| Solubility | H2O: soluble0.5 M at 20 °C, clear, colorless |
| Impurities tested | Insoluble matter, passes filter test≤3% Free alkali (as NaOH) |
| Application | Sodium phosphate tribasic dodecahydrate was used to prepare buffer solution used in the analysis of pyronaridine in human whole blood and plasma by using high-performance liquid chromatography.1 |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3262 8/PG 3 |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
| Anion traces | chloride (Cl-): ≤0.005%sulfate (SO42-): ≤0.005% |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Absorption | A0.5M/260, H2O ≤0.035A0.5M/280, H2O ≤0.023 |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Sodium phosphate tribasic dodecahydrate used for?
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Sodium phosphate tribasic dodecahydrate is primarily used for preparing buffer solutions, particularly in analytical techniques like high-performance liquid chromatography. It also serves as a general reagent in chemical synthesis and various laboratory applications.
What are the CAS number and formula for Sodium phosphate tribasic dodecahydrate?
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The CAS number is 10101-89-0 and the chemical formula is Na3PO4 · 12H2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Sodium phosphate tribasic dodecahydrate with an assay of ≥99.0%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade unless explicitly stated in the product specifications.
How should Sodium phosphate tribasic dodecahydrate be handled safely?
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This compound is classified as Danger, causing severe skin burns and eye damage (H314). Appropriate personal protective equipment, including eyeshields, faceshields, chemical-resistant gloves, and respiratory protection, is essential. Handle with extreme care to avoid contact and inhalation.
Is Sodium phosphate tribasic dodecahydrate a controlled substance?
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The provided data does not indicate that Sodium phosphate tribasic dodecahydrate is a controlled substance.
How is this product packed and shipped?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Specific packing and shipping details are available upon request, adhering to all relevant regulations for safe transport.
How can I request a sample or quote?
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To request a sample or a quote for Sodium phosphate tribasic dodecahydrate, please contact our sales team through the TSS website or your designated account manager.
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