Sodium deoxycholate monohydrate

CAS 145224-92-6C24H39NaO4 · H2OBiochemicals & Reagents

Sodium deoxycholate monohydrate (CAS 145224-92-6) is an anionic detergent with the chemical formula C24H39NaO4 · H2O and a molecular weight of 432.57. This bile salt serves as a powerful solubilization agent, particularly for membrane proteins. It is also utilized in antigen-vaccine preparation and various biochemical research applications. Supplied by Tech Serve Solutions with an assay of ≥99.0%, it is a valuable reagent for diverse laboratory needs.

IUPAC: 3α,12α-Dihydroxy-5β-cholanic acid sodium salt,7-Deoxycholic acid sodium salt,Desoxycholic acid sodium salt
Synonyms: 3α,12α-Dihydroxy-5β-cholanic acid sodium salt7-Deoxycholic acid sodium saltDesoxycholic acid sodium salt

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Sodium deoxycholate monohydrate (C24H39NaO4 · H2O) — chemical structure, CAS 145224-92-6; Life Science, fine chemical supplied by Tech Serve Solutions

Anionic DetergentsAntigen-Vaccine PreparationBile SaltsBiochemicals and ReagentsCell CultureCore BioreagentsDetergentsDetergents N to ZDetergents by ApplicationsDiagnostic Applications

01 /Applications

Membrane Protein Solubilization

Sodium deoxycholate monohydrate is a potent anionic detergent effective in solubilizing membrane proteins. It has been specifically used for the isolation of estrogen synthetase from human placental microsomes, demonstrating its utility in biochemical studies of membrane-bound enzymes.

Biochemical Research

As a bile salt and biochemical reagent, it finds application in various research settings. Its detergent properties aid in cell lysis and the extraction of biological molecules. Its use in molecular biology underscores its versatility in experimental procedures.

Antigen-Vaccine Preparation

This compound plays a role in the preparation of antigens and vaccines. Its ability to interact with biological structures makes it a useful component in certain immunochemical formulations and diagnostic applications.

Drug Delivery Systems

Sodium deoxycholate monohydrate can be employed in the development of drug delivery systems, including liposomes. Its amphipathic nature allows for the formation of structures that can encapsulate and transport therapeutic agents.

02 /Properties

Molecular weight	432.57
Empirical formula	C24H39NaO4 · H2O
Assay	≥99.0% (NT)
Solubility	H2O: soluble0.1 M at 20 °C, clear, colorless
pH	7.5-9.5 (25 °C, 0.1 M in H2O)
Optical activity	[α]20/D +44±2°, c = 2% in H2O
Impurities tested	insoluble matter, passes filter test≤0.5% cholic acid (TLC)≤6.1% water
Application	Powerful solubilization agent3,4; used in the solubilization of estrogen synthetase from human placental microsomes.5

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22-37
Safety statements (S)	22-36
Cation traces	Al: ≤20 mg/kgBa: ≤5 mg/kgBi: ≤5 mg/kgCd: ≤5 mg/kgCo: ≤5 mg/kgCr: ≤5 mg/kgCu: ≤5 mg/kgFe: ≤5 mg/kgLi: ≤5 mg/kgMg: ≤20 mg/kgMn: ≤5 mg/kgMo: ≤5 mg/kgNi: ≤5 mg/kgPb: ≤5 mg/kgSr: ≤20 mg/kgZn: ≤5 mg/kg
Anion traces	chloride (Cl-): ≤50 mg/kgsulfate (SO42-): ≤200 mg/kg

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

145224-92-6

MDL number

MFCD00150750

PubChem substance

24893956

Beilstein registry

3643164

05 /Additional specifications

Description	anionic
Product Line	BioXtra
Uv Absorption	λ: 260 nm Amax: 0.10λ: 280 nm Amax: 0.08
Absorption	A0.1M/260, H2O ≤0.10A0.1M/280, H2O ≤0.08
Aggregation Number	3-12
Cmc	2-6
Hlb	16

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Sodium Deoxycholate Monohydrate used for?

Sodium deoxycholate monohydrate is primarily used as a powerful solubilization agent, particularly for membrane proteins, and in applications such as antigen-vaccine preparation, cell culture, and biochemical research. It is also utilized in drug delivery systems and electrophoresis chromatography.

What is the CAS number and chemical formula for Sodium Deoxycholate Monohydrate?

The CAS number for Sodium Deoxycholate Monohydrate is 145224-92-6, and its empirical formula is C24H39NaO4 · H2O.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Sodium Deoxycholate Monohydrate with an assay of ≥99.0% (NT). This product is not classified as USP, BP, or EP grade unless explicitly stated, and is intended for laboratory and research use.

What are the main safety hazards associated with Sodium Deoxycholate Monohydrate?

Sodium deoxycholate monohydrate is classified as a GHS07 substance with a 'Warning' signal word. It is harmful if swallowed (H302) and may cause respiratory irritation (H335). Users should avoid breathing dust and wear appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves.

How is Sodium Deoxycholate Monohydrate packed and shipped?

Tech Serve Solutions securely packs and ships Sodium Deoxycholate Monohydrate according to international regulations for chemical export. Specific packaging details are available upon request for bulk or specialised orders.

How can I request a sample or quote for Sodium Deoxycholate Monohydrate?

To request a sample or obtain a quote for Sodium Deoxycholate Monohydrate, please contact our sales department through the TSS website or by phone, providing your specific quantity requirements and delivery details.