Sodium 1,1-difluoroethanesulfinate
Sodium 1,1-difluoroethanesulfinate (CAS: 1422738-67-7) is a fluorinated organosulfur compound with the molecular formula C2H3F2NaO2S and a molecular weight of 152.10 g/mol. It serves as a valuable reagent for the direct introduction of the 1,1-difluoroethyl group, particularly in the synthesis of fluorinated heteroarylether bioisosteres. Developed by the Baran Group, this compound facilitates C-C bond formation through robust and operationally simple protocols in chemical synthesis.
- IUPAC
- Baran DFES Reagent,Baran Difluoroethylation Reagent,DFES-Na Reagent,Sodium 1,1-difluoroethylsulfinate
- Synonyms
- C2H3F2NaO2SBaran DFES ReagentBaran Difluoroethylation ReagentDFES-Na ReagentSodium 1,1-difluoroethylsulfinate
Fluorinated Heterocycle Synthesis
This reagent enables a direct approach to fluorinated heteroarylether bioisosteres. It facilitates the appending of a 1,1-difluoroethyl group to various heterocyclic structures.
Direct Alkylation of Heterocycles
Developed by the Baran Group, DFES-Na is part of a suite of reagents designed for the direct alkylation of heterocycles. It offers a precise method for introducing difluoroethyl moieties.
C-C Bond Formation
As a Baran sulfinate, this compound is instrumental in forming new carbon-carbon bonds. Its application is key in constructing complex organic molecules requiring specific fluorinated substituents.
Chemical Synthesis Reagent
Primarily used as a synthetic reagent, DFES-Na is employed in academic and industrial research settings for developing novel organic compounds and exploring new synthetic methodologies.
| Molecular weight | 152.10 |
|---|---|
| Empirical formula | C2H3F2NaO2S |
| Assay | 95% |
| Application | DFES-Na provides a direct approach to fluorinated heteroarylether bioisosteres by appending a 1,1-difluoroethyl group operationally simple and robust protocol. This reagent was developed by the Baran Group and is one of several reagents for the direct alkylation of heterocycles. Learn More at the Professor and Product Portal of Professor Phil S. Baran. |
| Melting point | >300 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Sodium 1,1-difluoroethanesulfinate used for?
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Sodium 1,1-difluoroethanesulfinate (CAS: 1422738-67-7) is used for the direct introduction of the 1,1-difluoroethyl group in chemical synthesis, particularly for creating fluorinated heteroarylether bioisosteres and for the direct alkylation of heterocycles.
What are the CAS number and formula for Sodium 1,1-difluoroethanesulfinate?
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The CAS number for Sodium 1,1-difluoroethanesulfinate is 1422738-67-7, and its empirical formula is C2H3F2NaO2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Sodium 1,1-difluoroethanesulfinate with a minimum assay of 95%. This is a research-grade chemical and is not supplied as USP, BP, EP, or for nutraceutical or food applications.
How should Sodium 1,1-difluoroethanesulfinate be handled safely?
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Sodium 1,1-difluoroethanesulfinate is classified as a Warning substance. It can cause skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Always avoid breathing dust and ensure adequate ventilation. Wear protective gloves and eye protection. In case of contact with eyes, rinse cautiously with water for several minutes and seek medical advice. Store in a well-ventilated place.
Is Sodium 1,1-difluoroethanesulfinate a controlled substance?
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The provided data does not indicate that Sodium 1,1-difluoroethanesulfinate is a controlled substance.
How is this chemical packed and exported?
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Tech Serve Solutions professionally packs and exports fine chemicals, pharmaceutical intermediates, and laboratory reagents globally, adhering to all relevant shipping regulations.
How can I request a quote or sample?
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To request a quote or a sample of Sodium 1,1-difluoroethanesulfinate, please visit the product page on our website or contact our sales team directly.
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