(S)-(−)-N-(Trifluoroacetyl)pyrrolidine-2-carbonyl chloride solution

CAS 36724-68-2C7H7ClF3NO2Chemical Synthesis

(S)-(−)-N-(Trifluoroacetyl)pyrrolidine-2-carbonyl chloride solution (CAS: 36724-68-2; C7H7ClF3NO2; MW: 229.58) is a chiral acid halide. Supplied as a 0.1 M solution in methylene chloride, this compound is primarily utilised as a derivatizing agent. Its high optical purity (ee: 97%) makes it suitable for gas chromatographic analysis of chiral amines and alcohols, aiding in enantiomeric separation and quantification.

IUPAC: (S)-(−)-N-(Trifluoroacetyl)prolyl chloride solution,TPC

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(S)-(−)-N-(Trifluoroacetyl)pyrrolidine-2-carbonyl chloride solution (C7H7ClF3NO2) — chemical structure, CAS 36724-68-2; Chemistry, fine chemical supplied by Tech Serve Solutions

Acid HalidesAsymmetric SynthesisChemical SynthesisChiral Building BlocksOrganic Building Blocks

01 /Applications

Chiral Derivatization Agent

This compound serves as a derivatizing agent for the gas chromatographic (GC) assay of chiral amines and alcohols. It reacts with these analytes to form derivatives that are more volatile and readily separated on a chiral GC column.

Asymmetric Synthesis

As a chiral building block, it can be employed in asymmetric synthesis to introduce stereochemistry into target molecules. Its trifluoroacetyl group can also serve as a protecting or activating group in synthetic pathways.

GC Analysis of Enantiomers

The high optical purity (ee: 97%) makes it particularly useful for the enantioselective analysis of chiral compounds by GC, enabling accurate determination of enantiomeric excess.

02 /Properties

Molecular weight	229.58
Empirical formula	C7H7ClF3NO2
Density	1.308 g/mL at 25 °C
Refractive index	n20/D 1.424
Concentration	0.1 M in methylene chloride
Optical purity	ee: 97% (GLC)
Storage temperature	2-8°C
Application	Derivatizing agent for the GC assay of chiral amines and alcohols.

03 /Safety & handling

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements

P281Use personal protective equipment as required

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Transport (UN / ADR)	UN 1593 6.1 / PGIII
Water hazard class (WGK, DE)	2
Hazard codes (EU)	Xn
Risk statements (R)	40
Safety statements (S)	36/37

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

36724-68-2

MDL number

MFCD00010418

PubChem substance

24854932

Beilstein registry

480791

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (S)-(−)-N-(Trifluoroacetyl)pyrrolidine-2-carbonyl chloride solution used for?

(S)-(−)-N-(Trifluoroacetyl)pyrrolidine-2-carbonyl chloride solution is primarily used as a derivatizing agent for the gas chromatographic assay of chiral amines and alcohols, aiding in their enantiomeric separation and quantification.

What are the CAS number and chemical formula?

The CAS number is 36724-68-2, and the molecular formula is C7H7ClF3NO2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this product with a reported optical purity of ee: 97% (GLC) and as a 0.1 M solution in methylene chloride. We do not represent this product as USP, BP, EP or other pharmacopoeial grades.

What are the safety and handling considerations?

This compound is classified under GHS08 with a 'Warning' signal word, and carries the hazard statement H351 (Suspected of causing cancer). Appropriate personal protective equipment, including eyeshields, faceshields, gloves, and respiratory protection (e.g., multi-purpose combination respirator cartridge or AB EK type filter), is required. It is classified as WGK 2 in Germany and requires storage at 2-8°C.

How is this product shipped and exported?

This chemical is shipped and exported under UN 1593, hazard class 6.1, packing group III.

How can I request a sample or quote?

To request a sample or a quote for (S)-(−)-N-(Trifluoroacetyl)pyrrolidine-2-carbonyl chloride solution, please contact our sales department via the website or your dedicated account manager.