Retigabine

CAS 150812-12-7C16H18FN3O2Cell Biology

Retigabine (CAS: 150812-12-7, Formula: C16H18FN3O2) is a potassium channel modulator with a molecular weight of 303.33 g/mol. This white to light brown powder is known for its role in modulating voltage-gated ion channels, particularly potassium channels. It is commonly used in neuroscientific research and cell biology studies to investigate neuronal excitability and signaling pathways. Retigabine is classified as a USDEA Schedule V controlled substance.

IUPAC: D-23129,Ezogabine,N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester
Synonyms: EzogabineN-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester

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Retigabine (C16H18FN3O2) — chemical structure, CAS 150812-12-7; Life Science, fine chemical supplied by Tech Serve Solutions

Cell BiologyIon ChannelsMonovalent Ion ChannelsPotassium Channel Modulators

01 /Applications

Neuroscience Research

Retigabine is employed as a pharmacological tool to study the function of Kv7 potassium channels. Its ability to open these channels makes it valuable for understanding neuronal excitability and its role in various neurological processes.

Cellular Signaling Studies

As a modulator of ion channels, Retigabine aids in the investigation of cellular signaling pathways influenced by potassium flux. This is crucial for understanding complex biological responses at the cellular level.

Pharmacological Research

This compound serves as a reference standard or research chemical in the development and testing of new therapeutic agents targeting ion channelopathies and related neurological conditions.

02 /Properties

Molecular weight	303.33
Empirical formula	C16H18FN3O2
Assay	≥98% (HPLC)
Form	powder
Colour	white to light brown
Solubility	DMSO: >15 mg/mL
Storage temperature	room temp

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H319Causes serious eye irritation
H413May cause long-lasting harmful effects to aquatic life

Precautionary statements

P305IF IN EYES

Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36
Safety statements (S)	26

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

150812-12-7

Beilstein registry

8072099

05 /Additional specifications

Drug Control	USDEA Schedule V

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Retigabine primarily used for?

Retigabine is primarily used in neuroscience and cell biology research as a potassium channel opener to study neuronal excitability and cellular signaling.

What are the CAS number and formula for Retigabine?

The CAS number for Retigabine is 150812-12-7 and its empirical formula is C16H18FN3O2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Retigabine with a purity of ≥98% (HPLC). This product is intended for research purposes and is not supplied as USP, BP, or EP grade.

What are the safety considerations for handling Retigabine?

Retigabine is a warning substance (GHS07) and causes serious eye irritation (H319) and may cause long lasting harmful effects to aquatic life (H413). Handle with appropriate personal protective equipment, including eye protection, and avoid release into the environment. Refer to the Safety Data Sheet for detailed handling instructions.