(R)-2-(Boc-amino)-5-hexynoic acid
(R)-2-(Boc-amino)-5-hexynoic acid (CAS: 1217464-82-8, C11H17NO4) is a protected unnatural amino acid featuring a terminal alkyne. Its molecular weight is 227.26 g/mol. This compound is valuable in chemical synthesis, particularly for peptide chemistry and bioconjugation. It serves as a versatile building block for creating complex molecules and modified peptides due to its chiral centre and reactive alkyne functional group.
- IUPAC
- Boc-D-homopropargylglycine,Boc-D-Hpg-OH,Boc-D-homopropargyl-Gly-OH
Peptide Synthesis
This Boc-protected chiral amino acid is used in solid-phase and solution-phase peptide synthesis to introduce non-natural amino acid residues into peptide sequences. Its terminal alkyne allows for subsequent click chemistry modifications.
Bioconjugation Chemistry
The terminal alkyne moiety is ideal for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, enabling the conjugation of biomolecules such as proteins, peptides, or nucleic acids with other molecules.
Organic Synthesis Building Block
As a chiral building block, it is employed in the synthesis of complex organic molecules, pharmaceuticals, and other biologically active compounds where precise stereochemistry and functional group incorporation are critical.
Chemical Biology Research
Researchers utilise this compound in chemical biology to develop probes for studying biological processes, creating labelled molecules, or investigating protein-carbohydrate interactions through bioorthogonal chemistry.
| Molecular weight | 227.26 |
|---|---|
| Empirical formula | C11H17NO4 |
| Assay | ≥96% (HPLC) |
| Optical activity | [α]/D 80.0±2.0°, c = 1 in DMF |
| Composition | carbon, 57.0-59.3%nitrogen, 5.9-6.4% |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-2-(Boc-amino)-5-hexynoic acid used for?
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(R)-2-(Boc-amino)-5-hexynoic acid is primarily used as a building block in organic synthesis, peptide chemistry, and bioconjugation due to its Boc-protected amine and terminal alkyne functionalities. It allows for the introduction of non-natural residues into peptides and for click chemistry reactions.
What is the CAS number and formula for (R)-2-(Boc-amino)-5-hexynoic acid?
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The CAS number is 1217464-82-8 and the empirical formula is C11H17NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-2-(Boc-amino)-5-hexynoic acid with a purity of ≥96% (HPLC). TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades unless explicitly stated in the product documentation.
What are the safety and handling considerations for this compound?
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This compound is classified as a Warning with hazards including skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area. Dispose of in accordance with local regulations.
How is this chemical packed and shipped?
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Tech Serve Solutions ensures that all chemicals are packed securely in compliance with international shipping regulations. We export globally, adhering to all necessary protocols for safe and efficient transport.
How can I request a sample or quote?
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To request a sample or a quote for (R)-2-(Boc-amino)-5-hexynoic acid, please contact our sales team through the website or by phone, providing your specific requirements and shipping details.
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