Propyl chloroformate
Propyl chloroformate (CAS: 109-61-5), with the linear formula ClCO₂CH₂CH₂CH₃ and a molecular weight of 122.55 g/mol, is a reactive organic compound. It serves as a valuable building block and derivatization reagent in chemical synthesis. This acid halide is particularly employed in analytical chemistry for the quantification of biogenic amines and in the preparation of complex organic molecules.
Derivatization Reagent
Propyl chloroformate is utilised as a derivatization reagent in analytical methods, such as for the quantification of dopamine, serotonin, and norepinephrine in human urine using solid phase microextraction coupled with gas chromatography-triple quadrupole mass spectrometry.
Organic Synthesis Intermediate
This compound acts as a building block in organic synthesis. It has been employed in the preparation of various organic molecules, including dipropyl 3,6-diphenyl-1,2-dihydro-1,2,4,5-tetrazine-1,2-dicarboxylate.
Analytical Chemistry Reagent
As an analytical reagent, propyl chloroformate can be used in chromatography, including HPLC applications, for derivatization purposes to enhance detection or separation of specific analytes.
| Molecular weight | 122.55 |
|---|---|
| Linear formula | ClCO2CH2CH2CH3 |
| Assay | 98% |
| Boiling point | 105-106 °C(lit.) |
| Density | 1.09 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.404(lit.) |
| Solubility | benzene: miscible(lit.)chloroform: miscible(lit.)diethyl ether: miscible(lit.) |
| Vapour pressure | 0.87 psi (20 °C) |
| Storage temperature | 2-8°C |
| Application | Propyl chloroformate has been used:• as derivatization reagent in quantification of dopamine, serotonin and norepinephrine in human urine by solid phase microextraction-gas chromatography-triple quadrupole mass spectrometry1• in the preparation of dipropyl 3,6-diphenyl-1,2-dihydro-1,2,4,5-tetrazine-1,2-dicarboxylate2 |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 29 °C / 84.2 °F |
| Transport (UN / ADR) | UN 2740 6.1/PG 1 |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | F,T |
| Risk statements (R) | 11-23-34 |
| Safety statements (S) | 16-26-36-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Propyl chloroformate used for?
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Propyl chloroformate is used as a derivatization reagent in analytical chemistry, particularly for quantifying biogenic amines, and as a building block in organic synthesis.
What is the CAS number and formula for Propyl chloroformate?
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The CAS number for Propyl chloroformate is 109-61-5, and its linear formula is ClCO₂CH₂CH₂CH₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Propyl chloroformate with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should Propyl chloroformate be handled safely?
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Propyl chloroformate is a Danger material. It is highly flammable and causes severe skin burns and eye damage, and is toxic if inhaled. Handle with appropriate personal protective equipment including gloves, eye protection, and a respirator in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive handling information.
How is Propyl chloroformate packaged and shipped?
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Propyl chloroformate is packaged and shipped in compliance with relevant regulations for hazardous materials. As a global supplier and exporter, Tech Serve Solutions adheres to strict international shipping standards.
How can I request a sample or quote for Propyl chloroformate?
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To request a sample or a quote for Propyl chloroformate, please contact our sales team through the website or by phone.
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