Poly(ethylene glycol) (N-hydroxysuccinimide 5-pentanoate) ether N′-(3-maleimidopropionyl)aminoethane
Poly(ethylene glycol) (N-hydroxysuccinimide 5-pentanoate) ether N′-(3-maleimidopropionyl)aminoethane (CAS: 851040-94-3) is a heterobifunctional PEG linker with average molecular weight of 4,000. This compound features both a maleimide group, which reacts with thiols, and an NHS ester group, which reacts with amines. It is widely employed in bioconjugation, drug delivery systems, PEG hydrogel formation, and surface functionalisation.
- IUPAC
- Maleimide polyoxyethylene NHS-protected valeric acid,Maleimide-PEG-NHS protected acid,Maleimide-PEG-acid,maleimide-PEG-valeric acid
- Synonyms
- Maleimide-PEG-NHS EsterNHS Ester-PEG-MaleimideMaleimide polyoxyethylene NHS-protected valeric acidMaleimide-PEG-acidmaleimide-PEG-valeric acid
Bioconjugation
The maleimide and NHS ester functionalities enable precise conjugation of biomolecules. The maleimide group readily reacts with thiol groups on proteins or peptides, while the NHS ester reacts with amine groups on lysine residues or N-termini.
Drug Delivery
Its PEG backbone provides water solubility and stealth properties, crucial for developing advanced drug delivery vehicles. The reactive ends allow for attachment of drugs, targeting ligands, or other functional molecules.
Hydrogel Formation
This reagent can act as a crosslinker in the formation of PEG hydrogels. The bifunctional nature allows it to connect polymer chains, creating a crosslinked network suitable for tissue engineering and controlled release applications.
Surface Functionalisation
It can be used to modify surfaces, introducing specific reactive groups for further immobilisation of proteins, antibodies, or other biomolecules, enhancing biocompatibility or creating biosensors.
| Linear formula | C7H7N2O3(C2H4O)nC9H12NO4 |
|---|---|
| Storage temperature | −20°C |
| Application | Applications have been reported for: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization. |
| Flash point | >176 °C / >348.8 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Mol Wt | average Mn 4,000 |
|---|---|
| Transition Temp | Tm 46-51 °C |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Poly(ethylene glycol) (N-hydroxysuccinimide 5-pentanoate) ether N′-(3-maleimidopropionyl)aminoethane used for?
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This compound is primarily used in bioconjugation, drug delivery systems, PEG hydrogel formation, and surface functionalisation due to its heterobifunctional nature, featuring both maleimide and NHS ester groups.
What is the CAS number and formula for this PEG derivative?
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The CAS number is 851040-94-3 and the linear formula is C7H7N2O3(C2H4O)nC9H12NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an average Mn of 4,000. We do not represent this product as USP, BP, or EP grade. Please refer to the Certificate of Analysis for specific purity details.
What are the safety and handling requirements for this chemical?
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This chemical has a flash point above 176 °C and is classified under WGK Germany 3. Handle with appropriate personal protective equipment in a well-ventilated area. Avoid contact with skin and eyes.
How is this product typically shipped and exported?
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Tech Serve Solutions, as a global supplier and exporter, ensures products are packed and shipped according to international regulations for chemical transport.
How can I request a sample or quote for this product?
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To request a sample or a quotation, please contact our sales team through the website or by phone.
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