Phthaldialdehyde
Phthaldialdehyde (CAS: 643-79-8), with the chemical formula C8H6O2 and a molecular weight of 134.13 g/mol, is a yellow crystalline powder. It is primarily utilised in analytical chemistry for the precolumn derivatization of amino acids in High-Performance Liquid Chromatography (HPLC). This compound is also valuable in flow cytometry for quantifying protein thiol groups, playing a key role in biochemical research and diagnostics.
- IUPAC
- o-Phthalaldehyde,o-Phthalic dicarboxaldehyde,Benzene-1,2-dicarboxaldehyde,OPA
- Synonyms
- o-Phthalaldehydeo-Phthalic dicarboxaldehydeBenzene-1,2-dicarboxaldehydeOPA
Amino Acid Analysis
Phthaldialdehyde serves as a crucial reagent for the precolumn derivatization of amino acids, enabling sensitive detection and quantification via HPLC. This method is widely used in biochemical and clinical laboratories for protein hydrolysate analysis and physiological fluid studies.
Flow Cytometry
This compound is employed in flow cytometry for the detection and measurement of protein thiol groups. Its reactivity with thiols allows for the assessment of cellular redox status and the analysis of proteins within biological samples.
Biochemical Reagent
As a versatile biochemical reagent, Phthaldialdehyde is utilised in various synthetic and analytical procedures. Its aldehyde functionalities make it a useful building block in organic synthesis and for the development of fluorescent probes.
| Molecular weight | 134.13 |
|---|---|
| Empirical formula | C8H6O2 |
| Assay | ≥99% (HPLC) |
| Form | powder |
| Colour | light yellow |
| Storage temperature | 2-8°C |
| Application | For precolumn derivatization of amino acids for HPLC separation. For flow cytometric measurements of protein thiol groups. |
| Suitability | suitable for HPLC fluorimetric detection of amino acids |
Hazard statements
- H301Toxic if swallowed
- H314Causes severe skin burns and eye damage
- H317May cause an allergic skin reaction
- H400Very toxic to aquatic life
Precautionary statements
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 132 °C / 269.6 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T,N |
| Risk statements (R) | 25-34-43-50 |
| Safety statements (S) | 26-36/37/39-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Phthaldialdehyde used for?
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Phthaldialdehyde (CAS: 643-79-8) is used for the precolumn derivatization of amino acids for HPLC separation and for flow cytometric measurements of protein thiol groups.
What is the CAS number and chemical formula for Phthaldialdehyde?
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The CAS number for Phthaldialdehyde is 643-79-8, and its chemical formula is C8H6O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Phthaldialdehyde with a purity of ≥99% (HPLC). This is a technical/research grade material, and TSS does not represent it as USP, BP, or EP.
How should Phthaldialdehyde be handled safely?
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Phthaldialdehyde is a Danger substance, indicated by GHS05, GHS06, and GHS09 symbols. It is toxic if swallowed (H301), causes severe skin burns and eye damage (H314), may cause an allergic skin reaction (H317), and is very toxic to aquatic life (H400). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respirators, must be used. Handle in a well-ventilated area.
Is Phthaldialdehyde a controlled substance?
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The provided data does not indicate that Phthaldialdehyde is a controlled substance.
How is Phthaldialdehyde packed and shipped by TSS?
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Phthaldialdehyde is stored at 2-8°C. TSS, as a global supplier and exporter, ensures appropriate packaging and shipping procedures for fine chemicals.
How can I request a quote or sample for Phthaldialdehyde?
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Please contact Tech Serve Solutions directly through our website or sales department to request a quotation or a sample of Phthaldialdehyde.
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