O6-Benzylguanine
O6-Benzylguanine (CAS: 19916-73-5; Formula: C12H11N5O) is a chemical compound with a molecular weight of 241.25 g/mol. Supplied by Tech Serve Solutions as a solid, it is primarily recognised for its role in cellular processes, particularly in DNA repair mechanisms and apoptosis. This compound serves as a valuable reagent in biochemical research, aiding in the study of enzyme inhibition and cellular signalling pathways.
DNA Repair Research
O6-Benzylguanine is utilised as an inhibitor of alkylguanine-DNA alkyltransferase (MGMT), a key protein involved in DNA repair. Its application aids researchers in understanding the mechanisms of DNA damage and repair pathways.
Apoptosis and Cell Cycle Studies
This compound plays a role in research concerning apoptosis and cell cycle regulation. It can be used to investigate cellular responses to DNA damage and the pathways that control cell death and proliferation.
Enzyme Inhibition Studies
O6-Benzylguanine serves as a tool for studying enzyme inhibition, particularly concerning DNA repair enzymes. Researchers use it to probe enzyme activity and develop potential therapeutic strategies.
| Molecular weight | 241.25 |
|---|---|
| Empirical formula | C12H11N5O |
| Assay | ≥98% (TLC) |
| Form | solid |
| Solubility | methanol: soluble20 mg/mL |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... MGMT(4255) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O6-Benzylguanine used for?
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O6-Benzylguanine is primarily used in research as an inhibitor of alkylguanine-DNA alkyltransferase (MGMT) and in studies related to DNA repair, apoptosis, and cell cycle regulation.
What is the CAS number and formula for O6-Benzylguanine?
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The CAS number for O6-Benzylguanine is 19916-73-5, and its empirical formula is C12H11N5O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies O6-Benzylguanine with an assay of ≥98% (TLC). TSS does not represent this product as USP, BP, or EP grade.
What are the safety and handling considerations for O6-Benzylguanine?
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O6-Benzylguanine is a Warning substance (GHS07) with hazard statements H315, H319, and H335, indicating it may cause skin irritation, serious eye irritation, and respiratory irritation. Appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
How is O6-Benzylguanine packed, shipped, and exported?
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O6-Benzylguanine is supplied as a solid. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and can arrange for appropriate packaging and shipping compliant with international regulations.
How can I request a quote or sample for O6-Benzylguanine?
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To request a quote or a sample of O6-Benzylguanine, please contact our sales team through the TSS website or by calling our customer service line.
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