O-Desmethyltramadol
O-Desmethyltramadol (CAS: 80456-81-1) is a chemical compound with the formula C15H23NO2 and a molecular weight of 249.35 g/mol. It is recognised as a key metabolite of tramadol. This compound is primarily utilised in pharmacokinetic studies, particularly for investigating the metabolic pathways of tramadol in various biological systems, such as in animal models. O-Desmethyltramadol serves as a valuable research chemical for drug metabolism and neuroscience applications.
- IUPAC
- 2-[(Dimethylamino)methyl]-1-(3-hydroxyphenyl)cyclohexanol,O-Demethyl tramadol
- Synonyms
- 2-[(Dimethylamino)methyl]-1-(3-hydroxyphenyl)cyclohexanol,O-Demethyl tramadol

Pharmacokinetic Studies
O-Desmethyltramadol has been employed in research to study the pharmacokinetics of tramadol metabolites. Its use in studies involving goats has helped elucidate the metabolic profiles of tramadol in this species.
Neuroscience Research
As a significant metabolite of tramadol, O-Desmethyltramadol is a relevant compound for research in neuroscience. It can be used to investigate mechanisms related to pain perception and opioid receptor interactions within the central nervous system.
Drug Metabolism Studies
This compound serves as a valuable tool in drug and xenobiotic metabolism research. It aids in understanding the biotransformation processes of pharmaceuticals, particularly those involving O-demethylation pathways.
| Molecular weight | 249.35 |
|---|---|
| Empirical formula | C15H23NO2 |
| Storage temperature | 2-8°C |
| Application | O-Desmethyltramadol has been used for the pharmacokinetic studies of tramadol metabolites in goats1. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O-Desmethyltramadol used for?
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O-Desmethyltramadol is primarily used for pharmacokinetic studies of tramadol metabolites and in neuroscience research. It serves as a valuable tool for understanding drug metabolism and cell signaling pathways.
What is the CAS number and formula for O-Desmethyltramadol?
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The CAS number for O-Desmethyltramadol is 80456-81-1, and its empirical formula is C15H23NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies O-Desmethyltramadol as a research chemical. The specific assay and purity are available on the product's Certificate of Analysis. Tech Serve Solutions does not represent this product as USP, BP, or EP grade.
How should O-Desmethyltramadol be handled safely?
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Handling O-Desmethyltramadol requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. It is classified under WGK Germany 3, indicating a high hazard to water.
How is O-Desmethyltramadol packed, shipped, and exported?
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O-Desmethyltramadol is packed in appropriate containers suitable for chemical transport and adheres to all relevant shipping regulations. Tech Serve Solutions has extensive experience exporting fine chemicals globally.
How can I request a sample or quote for O-Desmethyltramadol?
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To request a sample or a quote for O-Desmethyltramadol, please contact the Tech Serve Solutions sales department via our website or direct email, providing your contact information and the product CAS number (80456-81-1).
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