NG,NG-Dimethylarginine dihydrochloride

CAS 220805-22-1C8H18N4O2 · 2HClBiochemicals & Reagents

N,N-Dimethylarginine dihydrochloride (CAS 220805-22-1) is a chemical compound with a molecular weight of 275.18 g/mol. This dihydrochloride salt is primarily recognised for its role as an inhibitor in nitric oxide metabolism and related enzymatic pathways. It is extensively used in biochemical research, particularly in studies concerning cell signaling enzymes and the broader field of cell biology. Its applications extend to neuroscience research and the investigation of enzyme kinetics and inhibition.

IUPAC: asym-Dimethylarginine,ADMA
Synonyms: asym-Dimethylarginine,ADMA

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NG,NG-Dimethylarginine dihydrochloride (C8H18N4O2 · 2HCl) — chemical structure, CAS 220805-22-1; Life Science, fine chemical supplied by Tech Serve Solutions

Application IndexBioactive Small MoleculesBiochemicals and ReagentsCell BiologyCell Signaling EnzymesDIG-DYEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitors

01 /Applications

Nitric Oxide Synthase Inhibition

N,N-Dimethylarginine dihydrochloride serves as a potent inhibitor for various isoforms of nitric oxide synthase (NOS), including NOS1, NOS2, and NOS3. This makes it a valuable tool for researchers studying the physiological and pathological roles of nitric oxide.

Cell Signaling Research

As a molecule involved in nitric oxide metabolism, it is employed in cell signaling studies. Researchers use it to investigate complex cellular communication pathways influenced by NO production and its regulation by enzymes like NOS.

Biochemical and Enzyme Assays

This compound is utilised in biochemical assays to understand enzyme mechanisms, particularly those involving arginine metabolism and nitric oxide production. It aids in the characterisation of enzyme inhibitors and substrates.

Neuroscience Investigations

Given the role of nitric oxide in neurotransmission and neurovascular coupling, N,N-Dimethylarginine dihydrochloride finds application in neuroscience research to probe these mechanisms.

02 /Properties

Molecular weight	275.18
Empirical formula	C8H18N4O2 · 2HCl

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

220805-22-1

MDL number

MFCD00270857

PubChem substance

24278027

05 /Additional specifications

Gene Information	human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is N,N-Dimethylarginine dihydrochloride used for?

N,N-Dimethylarginine dihydrochloride is used in biochemical research as an inhibitor of nitric oxide synthase (NOS) enzymes, for studying cell signaling pathways, in neuroscience research, and for enzyme assays investigating nitric oxide metabolism.

What is the CAS number and formula for N,N-Dimethylarginine dihydrochloride?

The CAS number is 220805-22-1 and the empirical formula is C8H18N4O2 · 2HCl.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this compound for research purposes. The specific grade and purity are detailed in the product specifications. We do not represent this product as USP, BP, EP, or suitable for pharmaceutical, nutraceutical, or food applications.

What are the safety and handling precautions for N,N-Dimethylarginine dihydrochloride?

According to GHS, this compound requires specific personal protective equipment, including eyeshields and gloves. A P1 (EN143) or N95 (US) respirator filter is recommended. It carries a WGK Germany rating of 3, indicating a high hazard to water.

How is N,N-Dimethylarginine dihydrochloride packed, shipped, and exported?

Tech Serve Solutions professionally packs and ships this chemical, adhering to all relevant transport regulations for international export. Detailed shipping and handling information is available upon request.

How can I request a sample or quote for N,N-Dimethylarginine dihydrochloride?

To request a sample or a quote, please visit the Tech Serve Solutions website or contact our sales department directly with your inquiry, referencing the product name and CAS number.