N-(Trimethylsilyl)acetamide
N-(Trimethylsilyl)acetamide (CAS 13435-12-6) is an organosilicon compound with the linear formula CH3CONHSi(CH3)3 and a molecular weight of 131.25 g/mol. This compound serves as a valuable reagent in organic synthesis. It is particularly useful as a silylating agent, facilitating the introduction of the trimethylsilyl group into various molecules, thereby modifying their reactivity and properties for further chemical transformations.
- IUPAC
- TMS acetamide
- Synonyms
- TMS acetamide
Silylating Agent
N-(Trimethylsilyl)acetamide is employed as a silylating agent in organic synthesis. It efficiently transfers the trimethylsilyl group, protecting hydroxyl or amine functionalities and altering the polarity and reactivity of substrates for subsequent reactions.
Building Block in Organic Synthesis
As an organic building block, this compound is utilised in the construction of more complex molecular structures. Its unique structure allows for its incorporation into diverse synthetic pathways, contributing to the development of novel compounds.
Chemical Intermediate
This chemical functions as an intermediate in multi-step syntheses. Its controlled reactivity makes it suitable for specific transformations required in the preparation of fine chemicals and pharmaceutical intermediates.
| Molecular weight | 131.25 |
|---|---|
| Linear formula | CH3CONHSi(CH3)3 |
| Assay | 95% |
| Boiling point | 84 °C/18 mmHg(lit.) |
| Melting point | 46-49 °C(lit.) |
Hazard statements
- H228Flammable solid
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 1325 4.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F |
| Risk statements (R) | 11 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(Trimethylsilyl)acetamide used for?
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N-(Trimethylsilyl)acetamide is primarily used as a silylating agent and an organic building block in chemical synthesis. It is valuable for introducing trimethylsilyl groups and participating in the construction of complex organic molecules.
What is the CAS number and formula for N-(Trimethylsilyl)acetamide?
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The CAS number for N-(Trimethylsilyl)acetamide is 13435-12-6, and its linear formula is CH3CONHSi(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-(Trimethylsilyl)acetamide with an assay of 95%. We do not represent this product as USP, BP, or EP grade.
What are the safety concerns when handling N-(Trimethylsilyl)acetamide?
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N-(Trimethylsilyl)acetamide is a flammable solid (H228). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area. Keep away from heat and open flames.
How is N-(Trimethylsilyl)acetamide packed and shipped?
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N-(Trimethylsilyl)acetamide is packed and shipped according to UN 1325, Class 4.1, Packing Group III regulations for flammable solids. It is exported globally by TSS.
How can I request a quote or sample for N-(Trimethylsilyl)acetamide?
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To request a quote or sample of N-(Trimethylsilyl)acetamide, please contact the Tech Serve Solutions sales department via our website or direct inquiry.
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