N,N′,N′′-Methylidynetrisformamide
N,N′,N′′-Methylidynetrisformamide (CAS 4774-33-8) is an organic compound with the linear formula (HCONH)₃CH and a molecular weight of 145.12 g/mol. This compound serves as a valuable building block and intermediate in various chemical synthesis applications. Its structure, featuring a central methane carbon bonded to three formamide groups, lends itself to specific reactivity profiles utilised in organic chemistry research and development. Available from Tech Serve Solutions with a 97% assay, it supports diverse synthetic pathways.
- IUPAC
- Tris-formaminomethane
- Synonyms
- 4774-33-8(HCONH)3CHTris-formaminomethane

Organic Synthesis Intermediate
N,N′,N′′-Methylidynetrisformamide acts as a key intermediate in the synthesis of more complex organic molecules. Its unique trifunctional amide structure allows for versatile derivatization in multi-step synthetic processes.
Building Block for Heterocycles
The compound can be employed as a building block for constructing heterocyclic ring systems. Its reactive sites are suitable for cyclization reactions commonly encountered in medicinal chemistry and materials science.
Reagent in Organic Chemistry
Utilised as a reagent in specific organic transformations, its formamide functionalities can participate in various condensation and addition reactions, contributing to the creation of diverse chemical entities.
| Molecular weight | 145.12 |
|---|---|
| Linear formula | (HCONH)3CH |
| Assay | 97% |
| Solubility | water: soluble25 mg/mL, clear, colorless |
| Melting point | 170-172 °C (dec.)(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N,N′,N′′-Methylidynetrisformamide used for?
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N,N′,N′′-Methylidynetrisformamide is primarily used as an intermediate and building block in organic synthesis and for the construction of heterocyclic compounds.
What is the CAS number and formula for N,N′,N′′-Methylidynetrisformamide?
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The CAS number is 4774-33-8, and the linear formula is (HCONH)₃CH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N,N′,N′′-Methylidynetrisformamide with a minimum assay of 97%. This product is typically considered for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
How should N,N′,N′′-Methylidynetrisformamide be handled safely?
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Handle with appropriate personal protective equipment including a dust mask (type N95 US), eyeshields, and gloves. Avoid breathing dust. In case of contact with eyes, rinse cautiously with water for several minutes, removing contact lenses if present and easy to do. Continue rinsing. Ensure adequate ventilation.
Is N,N′,N′′-Methylidynetrisformamide exported by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including N,N′,N′′-Methylidynetrisformamide.
How can I request a quote or sample for N,N′,N′′-Methylidynetrisformamide?
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To request a quote or sample, please use the contact form on the Tech Serve Solutions website or contact our sales department directly, referencing the product name and CAS number 4774-33-8.
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