N,N-Dimethylphosphoramic dichloride
N,N-Dimethylphosphoramic dichloride (CAS: 677-43-0) is a chemical compound with the molecular formula (CH3)2NP(O)Cl2 and a molecular weight of 161.95 g/mol. This organophosphorus halide serves as a valuable reagent and building block in organic synthesis, particularly for introducing the dimethylphosphinoyl group. It is commonly employed in the preparation of various organophosphorus compounds and intermediates within chemical research and development.
- IUPAC
- DMPADC,Dimethylamidophosphoric dichloride
- Synonyms
- (CH3)2NP(O)Cl2DMPADCDimethylamidophosphoric dichloride

Organic Synthesis
N,N-Dimethylphosphoramic dichloride acts as a key intermediate and building block in complex organic syntheses. Its reactive nature allows for efficient derivatization in the construction of novel organophosphorus molecules.
Phosphorus Compound Preparation
This compound is instrumental in the synthesis of a wide array of organophosphorus compounds. It facilitates the introduction of specific phosphorus-containing functionalities into target molecules.
Research and Development
Used in laboratory settings for exploring new synthetic pathways and developing novel materials or pharmaceuticals. Its defined reactivity makes it a predictable reagent for chemical transformations.
| Molecular weight | 161.95 |
|---|---|
| Linear formula | (CH3)2NP(O)Cl2 |
| Assay | ≥98.0% (AT) |
| Boiling point | 77-79 °C/11 mmHg(lit.) |
| Density | 1.362 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.464 |
| Storage temperature | 2-8°C |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N,N-Dimethylphosphoramic dichloride used for?
+
N,N-Dimethylphosphoramic dichloride is primarily used as a building block and reagent in organic synthesis, particularly for preparing other organophosphorus compounds and intermediates.
What is the CAS number and formula for N,N-Dimethylphosphoramic dichloride?
+
The CAS number is 677-43-0 and the linear formula is (CH3)2NP(O)Cl2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies N,N-Dimethylphosphoramic dichloride with a purity of ≥98.0% (AT). This is a technical/research grade, and TSS does not represent it as USP, BP, or EP grade.
How should N,N-Dimethylphosphoramic dichloride be handled?
+
N,N-Dimethylphosphoramic dichloride is a Danger hazard (H314), causing severe skin burns and eye damage. Handle with extreme care, using full personal protective equipment including face shield, goggles, gloves, and appropriate respiratory protection. Ensure adequate ventilation.
How is N,N-Dimethylphosphoramic dichloride packed and shipped?
+
N,N-Dimethylphosphoramic dichloride is classified as UN 3265, 8 / PG III. Shipments adhere to strict regulatory requirements for corrosive materials. TSS is a specialist global supplier and exporter experienced in handling such chemicals.
How can I request a sample or quote for N,N-Dimethylphosphoramic dichloride?
+
To request a sample or a quote, please contact the Tech Serve Solutions sales team through our website or by calling us directly. We will be happy to assist you with your inquiry.
▶ Related products

3,4,5-Trimethoxybenzylamine
Organic Building Blocks

3,4-dihydroxyphenylacetone
Organic Building Blocks

3-Fluoro-4-methoxybenzonitrile
C8H6FNO
Organic Building Blocks
4-Ethyltoluene
C2H5C6H4CH3
Organic Building Blocks
Fluoroacetic acid
C2H3FO2
Organic Building Blocks
Methoxyacetaldehyde
C3H6O2
Organic Building Blocks
Methyl 4-acetamido-5-chloro-2-methoxybenzoate
Organic Building Blocks

Methyl 5-bromo-2-iodobenzoate
BrC6H3(I)CO2CH3
Organic Building Blocks▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis