N,N-Bis(phosphonomethyl)glycine
N,N-Bis(phosphonomethyl)glycine (CAS: 2439-99-8) is an organic compound with the molecular formula C4H11NO8P2 and a molecular weight of 263.08. It functions as a complexing agent and has been investigated for its anti-diabetic properties, specifically in delaying the onset of diabetes in non-obese NOD mice by modifying T cell responses. This compound is valuable in chemical synthesis as an organic building block.
- IUPAC
- N-(Carboxymethyl)iminodi(methylphosphinic acid),Glyphosine
- Synonyms
- GlyphosineN-(Carboxymethyl)iminodi(methylphosphinic acid)
Complexing Agent
N,N-Bis(phosphonomethyl)glycine exhibits complexing properties, with several defined pK values (pK1: 2.0, pK2: 2.0, pK3: 5.20, pK4: 6.77, pK5: 10.89) indicating its potential in forming complexes with metal ions.
Research in Diabetes Management
Studies have indicated that Glyphosine (N,N-Bis(phosphonomethyl)glycine) can delay the onset of diabetes in specific mouse models (NOD mice). It achieves this by binding to MHC class II molecules and modifying T cell responses to autoantigenic peptides, potentially stimulating IL-10 production.
Chemical Synthesis
As an organic building block, this phosphonic acid derivative can be utilised in various chemical synthesis pathways for the development of novel compounds and materials.
| Molecular weight | 263.08 |
|---|---|
| Empirical formula | C4H11NO8P2 |
| Assay | ≥98.0% (T) |
| Application | Application: Complexing agent; pK-values: pK1: ·2, pK2: 2.0, pK3: 5.20, pK4: 6.77, pK5: 10.89 Anti-diabetic; delay onset of diabetes in non-obese NOD miceGlyphosine binds to a pocket of MHC class II molecules I-Ag7 and DQ8, and modify T cell responses to the autoantigenic insulin B chain fragment 9–23 (B:9–23) peptide. Glyphosine stimulate IL-10 production and delay onset of diabetes in non-obese NOD mice.† |
Hazard statements
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGIII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 41 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N,N-Bis(phosphonomethyl)glycine used for?
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N,N-Bis(phosphonomethyl)glycine is used as a complexing agent and has been researched for its potential in delaying the onset of diabetes. It also serves as a building block in chemical synthesis.
What is the CAS number and formula for N,N-Bis(phosphonomethyl)glycine?
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The CAS number is 2439-99-8, and the empirical formula is C4H11NO8P2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N,N-Bis(phosphonomethyl)glycine with an assay of ≥98.0% (T). We do not represent this product as USP, BP, or EP grade.
How should N,N-Bis(phosphonomethyl)glycine be handled safely?
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N,N-Bis(phosphonomethyl)glycine may cause serious eye damage. Handle with appropriate personal protective equipment, including eyeshields, gloves, and a dust mask (type N95 US). Ensure good ventilation and avoid dust formation. Store in a tightly closed container.
Is N,N-Bis(phosphonomethyl)glycine a controlled substance?
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Based on the provided data, N,N-Bis(phosphonomethyl)glycine is not listed as a controlled substance.
How is N,N-Bis(phosphonomethyl)glycine shipped?
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N,N-Bis(phosphonomethyl)glycine is shipped internationally under UN 3261, Hazard Class 8, Packing Group III, indicating it is a corrosive solid, acidic, organic, n.o.s.
How can I request a sample or quote for N,N-Bis(phosphonomethyl)glycine?
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To request a sample or a quote, please contact the Tech Serve Solutions sales team through our website or by phone, providing the product name and CAS number (2439-99-8).
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