N-Methyldibutylamine
N-Methyldibutylamine (CAS: 3405-45-6) is a tertiary amine with the chemical formula [CH3(CH2)3]2NCH3 and a molecular weight of 143.27 g/mol. This organic compound serves as a valuable building block in chemical synthesis. Its primary applications leverage its reactivity as an amine, particularly in research and development settings for creating more complex molecular structures and in specialised analytical techniques.
![N-Methyldibutylamine ([CH3(CH2)3]2NCH3) — chemical structure, CAS 3405-45-6; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F3405-45-6.png&w=3840&q=75)
Analytical Chemistry Reagent
N-Methyldibutylamine has been employed in the development of optimised mobile phase systems for high MS signal intensity in the analysis of nucleic acids like siRNA and DNA. This application highlights its utility in advanced analytical methodologies.
Organic Synthesis Building Block
As a tertiary amine, N-Methyldibutylamine functions as a key intermediate and building block in organic synthesis. It can be incorporated into various reaction pathways to construct complex nitrogen-containing molecules.
Research and Development
The compound is utilised in R&D laboratories for exploring new chemical reactions and developing novel compounds. Its specific properties make it a useful reagent for investigating amine-based chemistry.
| Molecular weight | 143.27 |
|---|---|
| Linear formula | [CH3(CH2)3]2NCH3 |
| Assay | 98% |
| Boiling point | 49-51 °C/10 mmHg(lit.) |
| Density | 0.745 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4178(lit.) |
| Application | N-Methyldibutylamine was used to identify a series of optimized mobile phase systems with 25 to 50mM hexafluoroisopropanol that yielded high MS signal intensity for both siRNA and DNA1. |



Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H311Toxic in contact with skin
- H314Causes severe skin burns and eye damage
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 42 °C / 107.6 °F |
| Transport (UN / ADR) | UN 2734PSN1 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-20/21/22-34 |
| Safety statements (S) | 16-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Methyldibutylamine used for?
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N-Methyldibutylamine is used as a building block in organic synthesis and has been applied in analytical chemistry to optimise mobile phase systems for mass spectrometry, enhancing signal intensity for nucleic acids.
What is the CAS number and chemical formula for N-Methyldibutylamine?
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The CAS number for N-Methyldibutylamine is 3405-45-6, and its chemical formula is [CH3(CH2)3]2NCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Methyldibutylamine with an assay of 98%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should N-Methyldibutylamine be handled safely?
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N-Methyldibutylamine is a dangerous substance. It is flammable (H226), harmful if swallowed (H302), toxic in contact with skin (H311), causes severe skin burns and eye damage (H314), and harmful if inhaled (H332). Handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection, in a well-ventilated area. Consult the Safety Data Sheet (SDS) for full details.
Is N-Methyldibutylamine a controlled substance?
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The provided data does not indicate that N-Methyldibutylamine is a controlled substance.
How is N-Methyldibutylamine packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports chemicals with adherence to all relevant regulations for hazardous materials. Specific packaging details depend on quantity and destination, ensuring safe transit.
How can I request a sample or quote for N-Methyldibutylamine?
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To request a sample or quote for N-Methyldibutylamine, please contact the Tech Serve Solutions sales team through our website or by phone. Provide your contact details and the required quantity.
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