N-Methyl-N-(trimethylsilyl)trifluoroacetamide
N-Methyl-N-(trimethylsilyl)trifluoroacetamide (CAS: 24589-78-4), with the molecular formula CF3CON(CH3)Si(CH3)3 and a molecular weight of 199.25 g/mol, is a valuable silylating agent. It is commonly employed in analytical chemistry for derivatization, particularly in gas chromatography, to enhance the volatility and detectability of various compounds. Its reactivity makes it suitable for protecting functional groups in organic synthesis.
- IUPAC
- N-Trimethylsilyl-N-methyl trifluoroacetamide,MSTFA
- Synonyms
- MSTFA - N-Methyl-N-(trimethylsilyl) trifluoroacetamideN-Trimethylsilyl-N-methyl trifluoroacetamide
Gas Chromatography Derivatization
N-Methyl-N-(trimethylsilyl)trifluoroacetamide is widely used as a derivatizing agent in gas chromatography. It converts polar compounds with active hydrogen atoms into more volatile and thermally stable trimethylsilyl derivatives, improving chromatographic separation and detection.
Organic Synthesis
This compound serves as a silylating agent in organic synthesis, enabling the protection of hydroxyl, carboxyl, and amine groups. This protection is crucial for directing reactions and preventing unwanted side reactions during complex molecule construction.
Drug Analysis
It finds application in the analysis of pharmaceuticals and biological samples, facilitating the detection and quantification of drugs and their metabolites through enhanced volatility for GC analysis. It is listed under the 'β-Glucuronidase Drug Analysis Bundle'.
| Molecular weight | 199.25 |
|---|---|
| Linear formula | CF3CON(CH3)Si(CH3)3 |
| Assay | ≥97.0% (GC) |
| Boiling point | 130-132 °C(lit.) |
| Density | 1.075 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.379n20/D 1.38(lit.) |
| Vapour pressure | 8.8 mmHg (27 °C) |
| Vapour density | >1 (vs air) |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 26 °C / 78.8 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Product Line | BioReagent |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Methyl-N-(trimethylsilyl)trifluoroacetamide used for?
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N-Methyl-N-(trimethylsilyl)trifluoroacetamide is primarily used as a silylating agent for derivatization in gas chromatography, enhancing the volatility and detectability of analytes. It is also employed in organic synthesis for protecting functional groups.
What is the CAS number and chemical formula?
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The CAS number is 24589-78-4, and the chemical formula is CF3CON(CH3)Si(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Methyl-N-(trimethylsilyl)trifluoroacetamide with an assay of ≥97.0% determined by GC. We do not represent this product as USP, BP, or EP grade.
What are the main safety hazards associated with this chemical?
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This compound is a flammable liquid and vapour (H226). It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335).
How is N-Methyl-N-(trimethylsilyl)trifluoroacetamide packed and shipped?
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As a global supplier and exporter, Tech Serve Solutions ensures N-Methyl-N-(trimethylsilyl)trifluoroacetamide is appropriately packed and shipped in compliance with international regulations for hazardous materials. Specific packaging details are available upon request.
How can I request a sample or quote?
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To request a sample or a quote for N-Methyl-N-(trimethylsilyl)trifluoroacetamide, please contact our sales team through the website or by phone.
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