N-Dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate
N-Dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate (CAS: 14933-08-5) is a zwitterionic detergent with a molecular weight of 335.55 g/mol. It is widely recognised for its utility in protein solubilisation, making it a valuable reagent in biochemical research. Its amphiphilic nature allows it to disrupt cell membranes and solubilise hydrophobic proteins while maintaining their biological activity. This compound is essential in various laboratory applications requiring mild detergent properties.
- IUPAC
- 3-(N,N-Dimethyldodecylammonio)propanesulfonate,3-(N,N-Dimethyllaurylammonio)propanesulfonate,3-(Dodecyldimethylammonio)propanesulfonate,3-(Lauryldimethylammonio)propanesulfonate,Dodecyldimethyl(3-sulfopropyl)ammonium hydroxide inner salt,Lauryl sulfobetaine,SB3-12
- Synonyms
- CH3(CH2)11N<sup>+</sup>(CH3)2CH2CH2CH2SO3<sup>-</sup>3-(N,N-Dimethyldodecylammonio)propanesulfonate3-(N,N-Dimethyllaurylammonio)propanesulfonate3-(Dodecyldimethylammonio)propanesulfonate3-(Lauryldimethylammonio)propanesulfonateDodecyldimethyl(3-sulfopropyl)ammonium hydroxide inner saltLauryl sulfobetaineSB3-12
Protein Solubilization
This zwitterionic detergent is effective in solubilising membrane proteins, aiding in their isolation and subsequent study. It helps to maintain protein structure and function during the extraction process.
Biochemical and Reagent Applications
Utilised as a core bioreagent in various biochemical assays and research applications. Its properties are beneficial for maintaining the stability and activity of enzymes and other biological molecules.
Cell Culture Studies
Can be employed in specific cell culture protocols where mild detergent activity is required for sample preparation or analysis. It is suitable for applications demanding careful maintenance of cellular integrity.
Electrophoresis and Chromatography
This detergent finds application in electrophoresis and chromatography techniques, particularly for the separation and purification of proteins. It helps to reduce non-specific binding and improve resolution.
| Molecular weight | 335.55 |
|---|---|
| Linear formula | CH3(CH2)11N+(CH3)2CH2CH2CH2SO3- |
| Solubility | H2O: soluble1 M at 20 °C, clear, colorless |
| Impurities tested | ≤0.0005% Phosphorus (P)≤0.1% Insoluble matter |
| Application | Zwitterionic detergent used for protein solubilization |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 22-24/25-26-36/37/39 |
| Cation traces | Al: ≤0.0005%Ca: ≤0.002%Cu: ≤0.0005%Fe: ≤0.0005%K: ≤0.005%Mg: ≤0.0005%NH4+: ≤0.05%Na: ≤0.005%Pb: ≤0.001%Zn: ≤0.0005% |
| Anion traces | chloride (Cl-): ≤0.05%sulfate (SO42-): ≤0.05% |
| Ignition residue | ≤0.1% |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Description | zwitterionic |
|---|---|
| Mol Wt | micellar avg mol wt 18,500 |
| Aggregation Number | 55 |
| Cmc | 2-4 mM(20-25°C) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate primarily used for?
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N-Dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate (CAS: 14933-08-5) is primarily used as a zwitterionic detergent for protein solubilisation, particularly for membrane proteins, helping to maintain their structure and activity in research applications.
What are the CAS number and formula for N-Dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate?
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The CAS number for N-Dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate is 14933-08-5. The linear formula is CH3(CH2)11N+(CH3)2CH2CH2CH2SO3-.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and laboratory use. The specific grade and purity are detailed in the product specifications, and we do not represent it as USP, BP, or EP grade unless explicitly stated.
How should N-Dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate be handled safely?
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Based on its GHS classification, this compound is a warning substance. Handle with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. Refer to the safety data sheet for comprehensive handling instructions.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions packs and ships this chemical in compliance with all relevant international regulations for the transport of chemicals. We are experienced exporters serving global markets.
How can I request a sample or quote for N-Dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate?
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To request a sample or a quotation, please contact our sales department through the website or by phone, providing the product name and CAS number (14933-08-5).
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