N-[3-(Trimethylsilyl)-2-propynyl]phthalimide
N-[3-(Trimethylsilyl)-2-propynyl]phthalimide (CAS 351029-12-4) is a versatile organic building block with the molecular formula C14H15NO2Si and a molecular weight of 257.36. It features a phthalimide moiety linked to a trimethylsilyl-protected alkyne. This compound is primarily utilised in organic synthesis as a precursor for introducing functionalised propargyl groups into more complex molecules, serving as a valuable intermediate in the creation of novel chemical entities.
- IUPAC
- 1-Phthalimido-3-(trimethylsilyl)propyne,2-[3-(Trimethylsilyl)-2-propynyl]-1H-isoindole-1,3(2H)-dione,N-[(Trimethylsilyl)propargyl]phthalimide
- Synonyms
- 1-Phthalimido-3-(trimethylsilyl)propyne2-[3-(Trimethylsilyl)-2-propynyl]-1H-isoindole-1,3(2H)-dioneN-[(Trimethylsilyl)propargyl]phthalimide
![N-[3-(Trimethylsilyl)-2-propynyl]phthalimide (C14H15NO2Si) — chemical structure, CAS 351029-12-4; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F351029-12-4.png&w=3840&q=75)
Organic Synthesis Intermediate
This compound acts as a key intermediate in organic synthesis, allowing for the facile introduction of the N-phthalimido-protected propargyl group. The trimethylsilyl protection facilitates handling and specific reaction pathways.
Building Block for Complex Molecules
Its unique structure makes it a valuable building block for constructing complex organic molecules, including pharmaceuticals and advanced materials. The phthalimide group can be readily cleaved to reveal a primary amine functionality.
Precursor in Click Chemistry
The terminal alkyne, after deprotection of the trimethylsilyl group, can participate in various cycloaddition reactions, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC), making it useful in the development of bioconjugates and functionalised polymers.
| Molecular weight | 257.36 |
|---|---|
| Empirical formula | C14H15NO2Si |
| Assay | 97% |
| Melting point | 131-136 °C |
Hazard statements
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-[3-(Trimethylsilyl)-2-propynyl]phthalimide used for?
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N-[3-(Trimethylsilyl)-2-propynyl]phthalimide is used as a versatile building block and intermediate in organic synthesis, particularly for introducing functionalised propargyl groups into complex molecules. It is also a precursor for click chemistry reactions after silyl deprotection.
What are the CAS number and formula for N-[3-(Trimethylsilyl)-2-propynyl]phthalimide?
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The CAS number for N-[3-(Trimethylsilyl)-2-propynyl]phthalimide is 351029-12-4, and its molecular formula is C14H15NO2Si.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-[3-(Trimethylsilyl)-2-propynyl]phthalimide with an assay of 97%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeial grade.
How should N-[3-(Trimethylsilyl)-2-propynyl]phthalimide be handled safely?
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N-[3-(Trimethylsilyl)-2-propynyl]phthalimide is classified as a Warning with Hazard Statement H319 (Causes serious eye irritation). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a dust mask (type N95 US recommended). Ensure adequate ventilation and avoid contact with eyes and skin. In case of eye contact, rinse cautiously with water for several minutes, removing contact lenses if present and easy to do, continuing rinsing.
Is N-[3-(Trimethylsilyl)-2-propynyl]phthalimide a controlled substance?
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The provided data does not indicate that N-[3-(Trimethylsilyl)-2-propynyl]phthalimide is a controlled substance.
How is N-[3-(Trimethylsilyl)-2-propynyl]phthalimide packed and exported?
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N-[3-(Trimethylsilyl)-2-propynyl]phthalimide is packed according to industry best practices to ensure safe transit and export. Please contact our sales team for specific shipping and export inquiries regarding your region.
How can I request a sample or quote for N-[3-(Trimethylsilyl)-2-propynyl]phthalimide?
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To request a sample or a quotation for N-[3-(Trimethylsilyl)-2-propynyl]phthalimide, please visit the product page on our website and use the 'Request Sample' or 'Request Quote' functions, or contact our dedicated sales team directly.
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