N-(3-Hydroxypropyl)trifluoroacetamide
N-(3-Hydroxypropyl)trifluoroacetamide (CAS: 78008-15-8) is a chemical compound with the formula C5H8F3NO2 and a molecular weight of 171.12 g/mol. This trifluoroacetyl-protected amino alcohol serves as a valuable building block in organic synthesis. Its bifunctional nature, featuring both an amide and a primary alcohol, allows for diverse chemical transformations and incorporation into more complex molecular structures, particularly in the fields of chemical biology and materials science.
- IUPAC
- 3-(Trifluoroacetamido)-1-propanol
Organic Synthesis Intermediate
N-(3-Hydroxypropyl)trifluoroacetamide is utilized as a key intermediate in the synthesis of complex organic molecules. The trifluoroacetyl group acts as a protecting group for the amine, allowing selective reactions at the hydroxyl moiety.
Chemical Biology Research
This compound can be employed in chemical biology to introduce trifluoroacetamido-propyl functionalities into biomolecules or probes. This modification can alter lipophilicity or provide a handle for further derivatization.
Linker and Crosslinker Development
Its bifunctional nature makes it suitable for the development of linkers and crosslinkers. The hydroxyl group can be activated for conjugation, while the protected amine can be deprotected and reacted under specific conditions.
Building Block for Specialty Chemicals
As an organic building block, it facilitates the construction of novel compounds with specific properties, finding use in the development of specialty chemicals and advanced materials.
| Molecular weight | 171.12 |
|---|---|
| Empirical formula | C5H8F3NO2 |
| Assay | ≥98.0% (GC) |
| Boiling point | 120-121 °C/0.03 mmHg(lit.) |
| Density | 1.355 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.406 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(3-Hydroxypropyl)trifluoroacetamide used for?
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N-(3-Hydroxypropyl)trifluoroacetamide (CAS: 78008-15-8) is primarily used as an intermediate in organic synthesis, a building block for specialty chemicals, and in chemical biology research. It is particularly useful for introducing trifluoroacetamido-propyl groups into molecules.
What is the CAS number and molecular formula for N-(3-Hydroxypropyl)trifluoroacetamide?
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The CAS number is 78008-15-8, and the molecular formula is C5H8F3NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-(3-Hydroxypropyl)trifluoroacetamide with an assay of ≥98.0% (GC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product specifications.
How should N-(3-Hydroxypropyl)trifluoroacetamide be handled safely?
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N-(3-Hydroxypropyl)trifluoroacetamide is classified as a Warning substance (GHS07) and may cause skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, should be used. Ensure adequate ventilation and avoid breathing dust/fume/gas/mist/vapours/spray. In case of contact with eyes, rinse cautiously with water for several minutes.
How is N-(3-Hydroxypropyl)trifluoroacetamide packaged and shipped?
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Tech Serve Solutions securely packages and exports chemicals globally, adhering to all relevant shipping regulations for hazardous materials. Specific packaging details can be provided upon request.
How can I request a quote or sample for N-(3-Hydroxypropyl)trifluoroacetamide?
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To request a quote or a sample of N-(3-Hydroxypropyl)trifluoroacetamide, please contact our sales team through the website or by phone. Our representatives will be pleased to assist you.
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