N-(2-Hydroxyethyl)trifluoroacetamide
N-(2-Hydroxyethyl)trifluoroacetamide (CAS: 6974-29-4) is a fluorinated organic compound with the linear formula CF3CONHCH2CH2OH and a molecular weight of 157.09 g/mol. This chemical serves as a valuable building block and intermediate in organic synthesis, particularly in the fields of chemical biology and for creating bifunctional linkers. Its structure, featuring both a trifluoroacetyl group and a hydroxyethyl moiety, allows for diverse chemical transformations and applications.
- IUPAC
- N-(Trifluoroacetyl)ethanolamine
- Synonyms
- N-(Trifluoroacetyl)ethanolamine
Organic Synthesis Intermediate
N-(2-Hydroxyethyl)trifluoroacetamide is employed as a key intermediate in the synthesis of more complex organic molecules. Its dual functionality allows for selective reactions at either the amide or alcohol group.
Chemical Biology Research
This compound finds application in chemical biology for the development of novel reagents and probes. The trifluoroacetyl group can influence lipophilicity and metabolic stability, while the alcohol provides a handle for further conjugation.
Bifunctional Linker Development
It can be utilised in the creation of bifunctional linkers, which are essential for conjugating different molecular entities in biochemical assays or drug delivery systems.
Method Development
The compound has been specifically utilised in research for developing microwave-mediated methods for O-allylation of amido alcohols on chromatographic alumina, showcasing its utility in advanced synthetic protocols.
| Molecular weight | 157.09 |
|---|---|
| Linear formula | CF3CONHCH2CH2OH |
| Assay | 97% |
| Density | 1.413 g/mL at 25 °C(lit.) |
| Application | Used in the development of a microwave-mediated method for O-allylation of amido alcohols on chromatographic alumina.1 |
| Melting point | 32-35 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 57 °C / 134.6 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(2-Hydroxyethyl)trifluoroacetamide used for?
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N-(2-Hydroxyethyl)trifluoroacetamide is primarily used as a building block and intermediate in organic synthesis, chemical biology research, and the development of bifunctional linkers. It has also been employed in the development of specific synthetic methodologies, such as microwave-mediated O-allylation.
What are the CAS number and formula for N-(2-Hydroxyethyl)trifluoroacetamide?
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The CAS number for N-(2-Hydroxyethyl)trifluoroacetamide is 6974-29-4, and its linear formula is CF3CONHCH2CH2OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-(2-Hydroxyethyl)trifluoroacetamide with a minimum purity of 97%. This product is supplied for research and development purposes and is not represented as USP, BP, or EP grade.
How should N-(2-Hydroxyethyl)trifluoroacetamide be handled safely?
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N-(2-Hydroxyethyl)trifluoroacetamide is a Warning substance (GHS07) that may cause respiratory irritation (H335), is harmful if swallowed (H302), harmful in contact with skin (H312), causes skin irritation (H315), causes serious eye irritation (H319), and harmful if inhaled (H332). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area.
Is N-(2-Hydroxyethyl)trifluoroacetamide available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including N-(2-Hydroxyethyl)trifluoroacetamide. Please contact us for export inquiries.
How can I request a sample or quote for N-(2-Hydroxyethyl)trifluoroacetamide?
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To request a sample or a quote for N-(2-Hydroxyethyl)trifluoroacetamide, please use the contact form on our website or contact our sales department directly.
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