N-(2-Fluorenyl)acetamide
N-(2-Fluorenyl)acetamide (CAS 53-96-3), also known as 2-Acetamidofluorene, is a genotoxic carcinogen with the molecular formula C15H13NO and a molecular weight of 223.27 g/mol. This chemical is primarily utilised in cancer research for inducing liver cancer in animal models, aiding in the study of carcinogenesis mechanisms. It also serves as a valuable reference material for its identification and quantitation in research settings.
- IUPAC
- 2-AAF,2-Acetamidofluorene,N-Acetyl-2-aminofluorene
- Synonyms
- 2-AAF2-AcetamidofluoreneN-Acetyl-2-aminofluorene
Induction of Liver Cancer in Animal Models
N-(2-Fluorenyl)acetamide is employed to reliably induce hepatocarcinogenesis in experimental animals, such as rats, making it instrumental in studying the aetiology and progression of liver cancer.
Carcinogenesis Mechanism Studies
Researchers utilise 2-AAF to investigate the fundamental molecular and cellular mechanisms underlying chemical-induced liver cancer, providing insights into genotoxicity and tumour development.
Reference Material
The compound serves as a certified reference material, essential for the accurate identification and precise quantitation of N-(2-Fluorenyl)acetamide in various biological and chemical matrices during research.
| Molecular weight | 223.27 |
|---|---|
| Empirical formula | C15H13NO |
| Assay | ≥98% (HPLC) |
| Application | N-(2-Fluorenyl)acetamide (2-Acetamidofluorene, 2-AAF), a genotoxic carcinogen, is used to induce liver cancer in animal models such as the 2-AAF/partial hepatectomy rat. 2-AAF may be used to study the mechanism of liver carcinogenesis and as a reference material during its identification or quantitation. |
| Melting point | 192-196 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H350May cause cancer
Precautionary statements
- P201Obtain special instructions before use
- P308IF exposed or concerned
| Protective equipment | Eyeshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3077 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 45-22 |
| Safety statements (S) | 53-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(2-Fluorenyl)acetamide primarily used for?
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N-(2-Fluorenyl)acetamide (CAS 53-96-3) is used in cancer research, specifically for inducing liver cancer in animal models and studying the mechanisms of carcinogenesis. It also functions as a reference material for its identification and quantitation.
What are the CAS number and chemical formula for N-(2-Fluorenyl)acetamide?
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The CAS number for N-(2-Fluorenyl)acetamide is 53-96-3, and its empirical formula is C15H13NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-(2-Fluorenyl)acetamide with a purity of ≥98% (HPLC). This is a technical/research grade material and is not represented as USP, BP, EP, or any other pharmacopoeia standard.
How should N-(2-Fluorenyl)acetamide be handled?
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N-(2-Fluorenyl)acetamide is a dangerous carcinogen (H350) and harmful if swallowed (H302). Handle with extreme caution in a well-ventilated area, wearing appropriate personal protective equipment including eyeshields, gloves, and a P2 respirator. Always follow stringent laboratory safety protocols and consult the Safety Data Sheet before use.
Is N-(2-Fluorenyl)acetamide regulated or controlled?
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N-(2-Fluorenyl)acetamide is classified as a carcinogen (T - Toxic) in Europe, with the risk statement R45 (May cause cancer). Strict adherence to safety protocols and handling guidelines is essential due to its hazardous nature.
How is N-(2-Fluorenyl)acetamide packed and shipped?
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N-(2-Fluorenyl)acetamide is typically packed and shipped according to international regulations for hazardous materials. Shipments are labelled with UN 3077, Class 9, Packing Group III.
How can I request a quote or sample?
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To request a quote or sample of N-(2-Fluorenyl)acetamide, please contact our sales department through the website or via direct email, providing your specific requirements and delivery details.
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