Mitoxantrone dihydrochloride
Mitoxantrone dihydrochloride (CAS: 70476-82-3), with the empirical formula C22H28N4O6 · 2HCl and a molecular weight of 517.40 g/mol, is a synthetic anthracenedione derivative. It functions as a DNA intercalator and topoisomerase II inhibitor, playing a role in cancer research and the study of apoptosis and cell cycle mechanisms. This compound is primarily utilised in laboratory settings for biochemical and cell biology investigations.
- IUPAC
- 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
Antitumor Agent Research
Mitoxantrone dihydrochloride is employed in preclinical research as a model compound for studying antitumorigenic mechanisms. Its DNA intercalating properties and ability to inhibit topoisomerase II make it valuable for investigating cancer cell proliferation and death pathways.
Apoptosis and Cell Cycle Studies
This chemical serves as a tool for researchers investigating programmed cell death (apoptosis) and the regulation of the cell cycle. Its known effects on DNA can induce cellular responses that are critical for understanding these fundamental biological processes.
DNA Interaction Studies
Utilised in molecular biology, Mitoxantrone dihydrochloride is used to probe DNA structure and function. Its well-defined interaction with DNA allows for detailed analysis of DNA-drug binding and modification.
| Molecular weight | 517.40 |
|---|---|
| Empirical formula | C22H28N4O6 · 2HCl |
| Assay | ≥97% (HPLC) |
Hazard statements
- H340May cause genetic defects
- H360May damage fertility or the unborn child
Precautionary statements
- P201Obtain special instructions before use
- P308IF exposed or concerned
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 46-61 |
| Safety statements (S) | 53-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Mitoxantrone dihydrochloride used for?
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Mitoxantrone dihydrochloride is used in scientific research, particularly in the fields of cancer research, apoptosis, cell cycle studies, and DNA interaction investigations. It serves as a DNA intercalator and topoisomerase II inhibitor.
What are the CAS number and formula for Mitoxantrone dihydrochloride?
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The CAS number for Mitoxantrone dihydrochloride is 70476-82-3, and its empirical formula is C22H28N4O6 · 2HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Mitoxantrone dihydrochloride with an assay of ≥97% (HPLC). TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades unless explicitly stated.
What are the primary safety concerns when handling Mitoxantrone dihydrochloride?
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Mitoxantrone dihydrochloride is classified with the GHS symbol GHS08 and the signal word 'Danger'. It carries hazard statements H340 (May cause genetic defects) and H360 (May damage fertility or the unborn child). Appropriate personal protective equipment, including eyeshields and suitable respiratory protection, must be used. Handle with extreme caution in designated areas.
How is Mitoxantrone dihydrochloride packed, shipped, and exported?
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Mitoxantrone dihydrochloride is carefully packed to ensure integrity during transit. As a global supplier, Tech Serve Solutions adheres to all relevant shipping and export regulations for chemical compounds.
How can I request a sample or a quote for Mitoxantrone dihydrochloride?
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To request a sample or a quote for Mitoxantrone dihydrochloride, please contact the Tech Serve Solutions sales department through our website or by phone, providing your contact details and required quantity.
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