Milrinone
Milrinone (CAS: 78415-72-2), a synthetic bipyridine derivative with the formula C12H9N3O and a molecular weight of 211.22 g/mol, is a phosphodiesterase 3 (PDE3) inhibitor. It functions as a cardiotonic agent by increasing intracellular cyclic adenosine monophosphate (cAMP) levels. This leads to positive inotropic and vasodilatory effects, making it valuable in treating acute decompensated heart failure.
- IUPAC
- 1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile
Cardiotonic Agent
Milrinone is used for its positive inotropic and vasodilatory properties in the short-term management of acute decompensated heart failure. Its mechanism involves inhibiting PDE3, leading to increased cAMP in cardiac and vascular smooth muscle.
Research Chemical
As a selective PDE3 inhibitor, Milrinone is utilised in pharmacological research to investigate cyclic nucleotide metabolism, signal transduction pathways, and cardiovascular physiology in various experimental models.
Cell Signaling Studies
Its role in modulating cAMP levels makes Milrinone a useful tool for researchers studying cellular signalling pathways, particularly those involving G proteins and cyclic nucleotides in cell biology and neuroscience.
| Molecular weight | 211.22 |
|---|---|
| Empirical formula | C12H9N3O |
| Assay | ≥97% (TLC) |
| Form | powder |
| Colour | off-white |
| Solubility | DMSO: >10 mg/mLH2O: insoluble |
| Storage temperature | 2-8°C |
Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25 |
| Safety statements (S) | 36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... PDE3A(5139), PDE3B(5140), PDE4B(5142), PDE5A(8654), PTPRA(5786)rat ... Pde3a(50678) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Milrinone used for?
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Milrinone is used as a cardiotonic agent for short-term treatment of acute decompensated heart failure and as a research chemical to study cyclic nucleotide metabolism and cell signalling.
What are the CAS number and chemical formula for Milrinone?
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The CAS number for Milrinone is 78415-72-2, and its chemical formula is C12H9N3O.
What grade and purity does Tech Serve Solutions supply for Milrinone?
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Tech Serve Solutions supplies Milrinone with a purity of ≥97% (TLC). We do not represent this product as USP, BP, or EP grade.
How should Milrinone be handled safely?
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Milrinone is acutely toxic and requires careful handling. It is classified with GHS06, Danger signal word, and carries hazard statements H301, H311, and H331. Always use appropriate personal protective equipment, including eyeshields, faceshields, gloves, and P2 respirator cartridges, and follow strict laboratory safety protocols.
Is Milrinone a controlled substance?
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The provided data indicates Milrinone is an approved therapeutic agent. It is classified under T (Toxic) hazard codes in Europe with risk statements R23/24/25. Please consult local regulations for specific handling and import/export requirements.
How is Milrinone packed and shipped?
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Milrinone is typically supplied as an off-white powder and is stored at 2-8°C. It is shipped according to relevant dangerous goods regulations (UN 2811 6.1 / PGIII).
How can I request a sample or quote for Milrinone?
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To request a sample or a quotation for Milrinone, please contact our sales team through the website or by phone, providing your specific requirements and shipping details.
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