(Methylsulfonyl)acetonitrile

CAS 2274-42-2CH3SO2CH2CNChemical Synthesis

(Methylsulfonyl)acetonitrile (CAS: 2274-42-2, Formula: CH3SO2CH2CN, MW: 119.14) is a versatile organic compound primarily utilised as a building block in chemical synthesis. Its structure, featuring both a sulfonyl and a nitrile group, allows for diverse reactions. It has been employed in the preparation of heterocyclic compounds, including substituted δ-pyrone ring analogues and pyrrolo[2,1-b]quinazolines. This reagent is supplied by Tech Serve Solutions with an assay of 97%.

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(Methylsulfonyl)acetonitrile (CH3SO2CH2CN) — chemical structure, CAS 2274-42-2; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksC1 to C5Chemical SynthesisCyanides/NitrilesNitrogen Compounds

01 /Applications

Synthesis of Substituted δ-Pyrone Ring Analogues

(Methylsulfonyl)acetonitrile serves as a key intermediate in the synthesis of substituted δ-pyrone ring analogues, contributing to the development of novel heterocyclic structures.

Preparation of Pyrrolo[2,1-b]quinazolines

This compound is utilised in the construction of 4,9-dihydropyrrolo[2,1-b]quinazolines, particularly those featuring electron-withdrawing groups at the 3-position.

Organic Building Block

As an organic building block, (Methylsulfonyl)acetonitrile offers valuable reactivity for creating complex molecules in various research and development settings.

02 /Properties

Molecular weight	119.14
Linear formula	CH3SO2CH2CN
Assay	97%
Application	(Methylsulfonyl)acetonitrile was used in the synthesis of:• substituted δ-pyrone ring analogues1 • 4,9-dihydropyrrolo[2,1-b]quinazolines containing electron withdrawing groups at the 3-position2
Melting point	81-84 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Transport (UN / ADR)	UN 3439 6.1 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	20/21/22
Safety statements (S)	22-26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

2274-42-2

MDL number

MFCD00014743

PubChem substance

24851111

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (Methylsulfonyl)acetonitrile used for?

(Methylsulfonyl)acetonitrile is used as a building block in organic synthesis, including the preparation of substituted δ-pyrone ring analogues and pyrrolo[2,1-b]quinazolines.

What are the CAS number and chemical formula for (Methylsulfonyl)acetonitrile?

The CAS number is 2274-42-2 and the chemical formula is CH3SO2CH2CN.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies (Methylsulfonyl)acetonitrile with an assay of 97%. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.

How should (Methylsulfonyl)acetonitrile be handled safely?

Handle (Methylsulfonyl)acetonitrile with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. It is classified as harmful if swallowed, in contact with skin, or if inhaled (H302-H312-H332).

How is (Methylsulfonyl)acetonitrile packed and shipped?

(Methylsulfonyl)acetonitrile is shipped according to UN 3439 6.1 / PGIII regulations, indicating it is classified as a hazardous material for transport.