Methylboronic acid
Methylboronic acid (CAS: 13061-96-6, CH3B(OH)2) is an organoboron compound with a molecular weight of 59.86. It is a key reagent in modern organic synthesis, primarily utilised in palladium-catalyzed cross-coupling reactions like the Suzuki-Miyaura coupling. This versatile compound serves as a fundamental building block for constructing complex molecules, finding extensive application in the development of pharmaceuticals, agrochemicals, and advanced materials.
- IUPAC
- Methaneboronic acid
- Synonyms
- Methaneboronic acid
Palladium-Catalyzed Cross-Couplings
Methylboronic acid is widely employed as a coupling partner in Suzuki-Miyaura and Stille reactions. These palladium-catalyzed processes are crucial for forming carbon-carbon bonds, essential in the synthesis of pharmaceuticals and agrochemicals.
Organic Synthesis Reagent
This compound acts as a valuable reagent in various synthetic transformations, including Ruthenium (Ru)-catalyzed silylation reactions and enantioselective asymmetric bromoaminocyclization.
Preparation of Pharmaceutical Intermediates
It serves as a precursor for synthesising common building blocks for pharmaceuticals and complex molecules, such as chrysin analogs and casein kinase I inhibitors.
Materials Science
Methylboronic acid is used in the preparation of catalysts, such as bis(aminotropone) Titanium (Ti) catalysts for ethylene polymerizations, contributing to advancements in polymer science.
| Molecular weight | 59.86 |
|---|---|
| Linear formula | CH3B(OH)2 |
| Assay | 97% |
| Application | Reagent used for• Palladium-catalyzed Stille and Suzuki-Miyaura cross-couplings1,2• Microwave-heated heterogeneous Palladium (Pd)-catalytized reactions3• Ruthenium (Ru)-catalyzed silylation reactions4• Bis(aminotropone) Titanium (Ti) catalysts for ethylene polymerizations5• Enantioselective asymmetric bromoaminocyclization and bromoaminocyclization using amino-thiocarbamate catalysts6,7Reagent used in Preparation of• Common building blocks for pharmaceuticals and agrochemicals8• Chrysin analogs by Suzuki-Miyaura coupling reactions9• Casein kinase I inhibitors10• Divergent C-H functionalizations directed by sulfonamide pharmacophores in drug discovery2 |
| Melting point | 91-94 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methylboronic acid used for?
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Methylboronic acid is primarily used as a reagent in palladium-catalyzed Suzuki-Miyaura and Stille cross-coupling reactions for C-C bond formation. It also finds application in preparing pharmaceutical building blocks, casein kinase I inhibitors, and in Ruthenium-catalyzed silylation reactions.
What is the CAS number and formula for Methylboronic acid?
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The CAS number for Methylboronic acid is 13061-96-6, and its linear formula is CH3B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methylboronic acid with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should Methylboronic acid be handled?
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Methylboronic acid is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment including Eyeshields, Gloves, and a dust mask type N95 (US). Ensure good ventilation.
Is Methylboronic acid available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Methylboronic acid. Please contact us for export inquiries.
How can I request a quote or sample for Methylboronic acid?
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To request a quote or sample for Methylboronic acid, please use the contact form on our website or contact our sales department directly.
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