(+)-Methyl L-β-hydroxyisobutyrate
(+)-Methyl L-β-hydroxyisobutyrate (CAS: 80657-57-4, C5H10O3, MW: 118.13) is a chiral ester vital for asymmetric synthesis and chemical manufacturing. This optically active compound, exhibiting specific rotation of +26±1°, serves as a key building block in organic chemistry. Its high optical purity (ee: 99%) makes it suitable for intricate synthetic pathways requiring precise stereochemical control in the development of pharmaceuticals and fine chemicals.
- IUPAC
- (+)-Methyl (S)-3-hydroxy-2-methylpropionate,S-(+)-3-Hydroxy-2-methylpropionic acid methyl ester
Asymmetric Synthesis
Utilised as a chiral building block in stereoselective syntheses, enabling the formation of enantiomerically pure target molecules. Its defined stereochemistry is crucial for producing complex chiral compounds.
Pharmaceutical Intermediates
Serves as a precursor or intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its chiral nature is often essential for the biological activity of final drug products.
Organic Building Blocks
A versatile organic building block employed in the construction of more complex molecular architectures. It provides a readily available source of chirality for various organic transformations.
Chemical Synthesis
Incorporated into various chemical synthesis schemes where a chiral hydroxy ester moiety is required. It facilitates the development of novel chemical entities.
| Molecular weight | 118.13 |
|---|---|
| Empirical formula | C5H10O3 |
| Assay | ≥95.0% (sum of enantiomers, GC) |
| Boiling point | 74-76 °C/12 mmHg(lit.) |
| Density | 1.066 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.425 |
| Optical activity | [α]20/D +26±1°, c = 2% in methanol |
| Optical purity | ee: 99% (GLC) |
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 80 °C / 176 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (+)-Methyl L-β-hydroxyisobutyrate used for?
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(+)-Methyl L-β-hydroxyisobutyrate is primarily used in asymmetric synthesis, as a chiral building block, for chemical synthesis, and as an intermediate in the development of pharmaceuticals and fine chemicals.
What is the CAS number and formula for (+)-Methyl L-β-hydroxyisobutyrate?
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The CAS number is 80657-57-4, and the empirical formula is C5H10O3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (+)-Methyl L-β-hydroxyisobutyrate with an assay of ≥95.0% (sum of enantiomers, GC) and an optical purity of ee: 99% (GLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should (+)-Methyl L-β-hydroxyisobutyrate be handled safely?
+
Handle with appropriate personal protective equipment, including eyeshields and gloves. Ensure adequate ventilation and use a suitable respirator filter (e.g., type ABEK). Refer to the Safety Data Sheet for detailed handling and hazard information. It is classified as NA 1993 / PGIII for transport and has a flash point of 80 °C.
Is this chemical suitable for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, including (+)-Methyl L-β-hydroxyisobutyrate.
How can I request a sample or quote for (+)-Methyl L-β-hydroxyisobutyrate?
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Please contact our sales team via the website or direct inquiry to request a sample or a quotation for (+)-Methyl L-β-hydroxyisobutyrate.
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