Methyl 4-aminobenzoate
Methyl 4-aminobenzoate (CAS: 619-45-4), with the molecular formula H2NC6H4CO2CH3 and a molar mass of 151.16 g/mol, is a versatile organic compound. This aromatic ester is primarily utilised as a building block in chemical synthesis. It has been employed in the creation of complex molecules, including guanidine alkaloids like martinelline and martinellic acid, through established organic reactions.
Synthesis of Guanidine Alkaloids
Methyl 4-aminobenzoate served as a key reactant in the synthesis of guanidine alkaloids, specifically (±)-martinelline and (±)-martinellic acid. This was achieved via a protic acid catalyzed hetero Diels-Alder coupling reaction with N-Cbz 2-pyrroline.
Organic Building Block
As an ester with an amine functional group, this compound is a valuable intermediate in organic synthesis. Its structure allows for various chemical transformations, making it suitable for constructing more complex molecular architectures.
Chemical Synthesis Intermediate
The compound's reactivity profile makes it useful in multi-step synthesis pathways. It can participate in reactions involving both its ester and amine functionalities for the development of novel chemical entities.
| Molecular weight | 151.16 |
|---|---|
| Linear formula | H2NC6H4CO2CH3 |
| Assay | 98% |
| Application | Methyl 4-aminobenzoate was used in the syntheses of guanidine alkaloids, (±)-martinelline and (±)-martinellic acid by a protic acid catalyzed hetero Diels-Alder coupling reaction with N-Cbz 2-pyrroline1. |
| Melting point | 110-111 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl 4-aminobenzoate used for?
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Methyl 4-aminobenzoate is used as a building block in chemical synthesis, notably in the preparation of guanidine alkaloids such as martinelline and martinellic acid.
What are the CAS number and molecular formula for Methyl 4-aminobenzoate?
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The CAS number for Methyl 4-aminobenzoate is 619-45-4, and its molecular formula is H2NC6H4CO2CH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl 4-aminobenzoate with an assay of 98%. This product is supplied for research and chemical synthesis purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling considerations for Methyl 4-aminobenzoate?
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Methyl 4-aminobenzoate is classified with GHS07 and a Warning signal word. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask type N95, eyeshields, and gloves, should be used. Ensure adequate ventilation and avoid breathing dust.
Is Methyl 4-aminobenzoate exported by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Methyl 4-aminobenzoate.
How can I request a quote or sample for Methyl 4-aminobenzoate?
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To request a quote or sample for Methyl 4-aminobenzoate, please contact our sales team via the website or listed contact details, providing your specific requirements.
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