MePhos
MePhos (CAS: 251320-86-2; C25H33P) is a highly effective phosphine ligand with a molecular weight of 364.50 g/mol. It is recognised for its utility in promoting challenging cross-coupling reactions, particularly those involving arylations. As a key Buchwald ligand, MePhos facilitates Suzuki-Miyaura and Buchwald-Hartwig couplings, enabling efficient carbon-carbon and carbon-heteroatom bond formation in advanced chemical synthesis.
- IUPAC
- 2-Dicyclohexylphosphino-2′-methylbiphenyl,2-Methyl-2′-dicyclohexylphosphinobiphenyl,MebiphPCy2
- Synonyms
- 2-Dicyclohexylphosphino-2′-methylbiphenyl2-Methyl-2′-dicyclohexylphosphinobiphenylMebiphPCy2
Suzuki-Miyaura Coupling
MePhos serves as a vital ligand in palladium-catalysed Suzuki-Miyaura reactions, facilitating the formation of carbon-carbon bonds through the coupling of organoboron compounds with organic halides or pseudohalides.
Buchwald-Hartwig Amination
This phosphine ligand is instrumental in palladium-catalysed Buchwald-Hartwig amination reactions, enabling the efficient construction of carbon-nitrogen bonds by coupling amines with aryl halides or pseudohalides.
Arylations
MePhos is extensively employed in catalysing various arylation reactions, promoting the introduction of aryl groups onto different substrates with high efficiency and selectivity.
Palladium-Catalysed Cross-Coupling
As a member of the Buchwald ligand family, MePhos is widely used in diverse palladium-catalysed cross-coupling methodologies, offering solutions for complex synthetic challenges in organic chemistry.
| Molecular weight | 364.50 |
|---|---|
| Empirical formula | C25H33P |
| Assay | 97% |
| Melting point | 105-109 °C |
| Ligand For | ArylationsBuchwald-Hartwig Cross Coupling ReactionSuzuki-Miyaura Coupling |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is MePhos used for?
+
MePhos is primarily used as a phosphine ligand in palladium-catalysed cross-coupling reactions, including Suzuki-Miyaura couplings and Buchwald-Hartwig aminations, and for general arylations.
What is the CAS number and chemical formula for MePhos?
+
The CAS number for MePhos is 251320-86-2, and its chemical formula is C25H33P.
What grade and purity does Tech Serve Solutions supply for MePhos?
+
Tech Serve Solutions supplies MePhos at a purity of 97%. This product is typically supplied as a research or technical grade material and is not represented as USP/BP/EP.
How should MePhos be handled?
+
MePhos is classified under WGK 2 (Water Hazard Class 2), indicating it is hazardous to aquatic life. Handle with appropriate personal protective equipment in a well-ventilated area to avoid exposure.
Does Tech Serve Solutions export MePhos?
+
Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including MePhos, serving customers worldwide.
How can I request a quote or sample of MePhos?
+
To request a quote or sample of MePhos, please visit the Tech Serve Solutions website or contact our sales department directly with your inquiry.
▶ Related products
Benzeneruthenium(II) chloride dimer
Ru2(C6H6)2Cl4
Catalysis & Inorganic
Benzoylferrocene
C17H14FeO
Catalysis & Inorganic
Benzyldiphenylphosphine
C6H5CH2P(C6H5)2
Catalysis & Inorganic
Beryllium
Be
Catalysis & Inorganic
Beryllium oxide
BeO
Catalysis & Inorganic![Bicyclo[2.2.1]hepta-2,5-diene-rhodium(I) chloride dimer — chemical structure, CAS 12257-42-0; Catalysis & Inorganic, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F12257-42-0.png&w=3840&q=75)
Bicyclo[2.2.1]hepta-2,5-diene-rhodium(I) chloride dimer
Catalysis & Inorganic
![Bis[(10,11-η)-5-[(11bS)-dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl- κP4]-5H-dibenz[b,f]azepine]rhodium(I) tetrafluorobo — chemical structure, CAS 1228149-03-8; Catalysis & Inorganic, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F1228149-03-8.png&w=3840&q=75)
Bis[(10,11-η)-5-[(11bS)-dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl- κP4]-5H-dibenz[b,f]azepine]rhodium(I) tetrafluorobo
1-d:1′
Catalysis & Inorganic![Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride (C16H20ClN3Ni) — chemical structure, CAS 1033772-47-2; Catalysis & Inorganic, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F1033772-47-2.png&w=3840&q=75)
Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride
C16H20ClN3Ni
Catalysis & Inorganic▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis