Magnesium bis(hexamethyldisilazide)

CAS 857367-60-3C12H36MgN2Si4Acids & Bases

Magnesium bis(hexamethyldisilazide), CAS 857367-60-3, has the empirical formula C12H36MgN2Si4 and a molecular weight of 345.07 g/mol. This powerful organometallic compound functions as a strong, non-nucleophilic base. It is widely employed in organic synthesis, particularly for deprotonation reactions where high basicity and steric hindrance are required. Its reactivity necessitates careful handling due to its violent reaction with water.

IUPAC: Bis(hexamethyldisilazido)magnesium,Mg(HMDS)2
Synonyms: Bis(hexamethyldisilazido)magnesium, Mg(HMDS)2

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Magnesium bis(hexamethyldisilazide) (C12H36MgN2Si4) — chemical structure, CAS 857367-60-3; Chemistry, fine chemical supplied by Tech Serve Solutions

Acids & BasesBasesChemical SynthesisOrganic BasesSynthetic Reagents

01 /Applications

Strong Non-Nucleophilic Base

Magnesium bis(hexamethyldisilazide) serves as an effective strong base in organic synthesis. Its sterically hindered nature minimises unwanted nucleophilic side reactions, making it ideal for selective deprotonations.

Deprotonation Reactions

This compound is frequently used to generate enolates from carbonyl compounds and other reactive carbanions. Its high basicity facilitates the abstraction of even weakly acidic protons.

Organometallic Chemistry

As a magnesium-based reagent, it finds utility in various organometallic transformations and as a precursor for other magnesium-containing species in research and development.

02 /Properties

Molecular weight	345.07
Empirical formula	C12H36MgN2Si4
Assay	97%
Melting point	121-124 °C

03 /Safety & handling

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES
P310Immediately call a POISON CENTER or doctor

Protective equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 3263 8 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	C
Risk statements (R)	14-34
Safety statements (S)	26-36/37/39-45
Supplemental hazards	Reacts violently with water.

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

857367-60-3

MDL number

MFCD11656057

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Magnesium bis(hexamethyldisilazide) used for?

Magnesium bis(hexamethyldisilazide) (CAS 857367-60-3) is primarily used as a strong, non-nucleophilic base in organic synthesis for deprotonation reactions, such as enolate formation.

What is the CAS number and chemical formula?

The CAS number for Magnesium bis(hexamethyldisilazide) is 857367-60-3, and its empirical formula is C12H36MgN2Si4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Magnesium bis(hexamethyldisilazide) with an assay of 97%. We do not represent this product as USP, BP, EP, or for pharmaceutical, nutraceutical, or food use.

How should Magnesium bis(hexamethyldisilazide) be handled safely?

Magnesium bis(hexamethyldisilazide) is a Danger hazard (H314) that reacts violently with water. Appropriate personal protective equipment including eyeshields, faceshields, gloves, and suitable respirators must be worn. Handle in a well-ventilated area away from moisture.

How is this chemical packed and shipped?

This chemical is packed and shipped according to its UN classification (UN 3263, 8 / PG II), adhering to stringent international regulations for hazardous materials transport.

How can I request a quote or sample?

To request a quote or a sample of Magnesium bis(hexamethyldisilazide), please contact the TSS sales team through our website or by phone, providing your specific requirements.