LY-364947
LY-364947 (CAS: 396129-53-6), a bioactive small molecule with the empirical formula C17H12N4 and a molecular weight of 272.30, is a tan solid. This compound is recognised as a potent inhibitor of transforming growth factor-beta receptor I (TGFBR1). Its applications are primarily within biochemical research, focusing on cell signalling pathways and the study of cytokines and growth factors.
- IUPAC
- 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline,HTS 466284,Transforming Growth Factor-β Type I Receptor Kinase Inhibitor
TGF-β Pathway Research
LY-364947 is a selective inhibitor of the TGF-β type I receptor kinase (TGFBR1). It is instrumental in studying the downstream signalling effects of TGF-β, crucial for understanding cell growth, differentiation, and immune responses.
Cell Biology Studies
As a bioactive small molecule, LY-364947 finds use in cell biology to investigate processes regulated by the TGF-β pathway, including apoptosis, cell migration, and extracellular matrix production.
Neuroscience Research
The compound's ability to modulate cell signalling pathways makes it a valuable tool in neuroscience research, particularly in exploring the role of TGF-β signalling in neuronal function and disease.
| Molecular weight | 272.30 |
|---|---|
| Empirical formula | C17H12N4 |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | tan |
| Solubility | H2O: DMSO: >5 mg/mL |
| Storage temperature | 2-8°C |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H400Very toxic to aquatic life
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T,N |
| Risk statements (R) | 25-36/37/38-50/53 |
| Safety statements (S) | 26-45-60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... TGFBR1(7046) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is LY-364947 used for?
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LY-364947 is primarily used as a research chemical for studying the transforming growth factor-beta (TGF-β) signalling pathway, particularly as an inhibitor of TGFBR1, and in cell biology and neuroscience research.
What is the CAS number and formula for LY-364947?
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The CAS number for LY-364947 is 396129-53-6 and its empirical formula is C17H12N4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies LY-364947 with a purity of ≥98% as determined by HPLC. We do not represent this product as USP, BP, or EP grade.
How should LY-364947 be handled safely?
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LY-364947 is labelled with Danger and is toxic if swallowed (H301), causes skin irritation (H315), causes serious eye irritation (H319), may cause respiratory irritation (H335), and is very toxic to aquatic life (H400). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and P2 respirator cartridges, is required. Handle in a well-ventilated area and avoid release to the environment. Refer to the safety data sheet for comprehensive handling instructions.
How is LY-364947 shipped and exported?
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LY-364947 is shipped as a solid and is classified under UN 2811, Hazard Class 6.1, Packing Group III. We are experienced global exporters of fine chemicals.
How can I request a quote or sample for LY-364947?
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To request a quote or sample of LY-364947, please use the contact form on our website or contact our sales team directly.
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