Lithium phenylacetylide solution
Lithium phenylacetylide solution (CAS: 4440-01-1, Formula: C6H5C≡CLi, MW: 108.07) is a reactive organolithium reagent supplied by TSS as a 1.0 M solution in Tetrahydrofuran (THF). This compound serves as a versatile intermediate in organic synthesis, particularly for introducing the phenylethynyl group into various molecular structures. Its utility spans the development of complex organic molecules and materials.
- IUPAC
- (Phenylethynyl)lithium
- Synonyms
- (Phenylethynyl)lithium
Alkynylation Reactions
Lithium phenylacetylide acts as a nucleophile in alkynylation reactions, enabling the formation of new carbon-carbon bonds. It is valuable for the synthesis of functionalised alkynes and conjugated systems.
Intermediate in Fine Chemical Synthesis
This organolithium reagent is employed in multi-step syntheses within the fine chemical industry. It facilitates the construction of elaborate molecular architectures required for pharmaceuticals and advanced materials.
Organometallic Chemistry
As an organometallic compound, it participates in various transformations characteristic of organolithium species. This includes reactions with electrophiles such as carbonyl compounds and alkyl halides.
| Molecular weight | 108.07 |
|---|---|
| Linear formula | C6H5C≡CLi |
| Density | 0.91 g/mL at 25 °C |
| Concentration | 1.0 M in THF |
Hazard statements
- H225Highly flammable liquid and vapour
- H261In contact with water releases flammable gas
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P231Handle under inert gas
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -17 °C / 1.4 °F |
| Transport (UN / ADR) | UN 3399 4.3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-19-34-37 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Lithium phenylacetylide solution used for?
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Lithium phenylacetylide solution is primarily used as a reagent in organic synthesis, particularly for alkynylation reactions to introduce the phenylethynyl group into organic molecules and as an intermediate in the synthesis of fine chemicals.
What is the CAS number and formula for Lithium phenylacetylide solution?
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The CAS number for Lithium phenylacetylide solution is 4440-01-1, and its linear formula is C6H5C≡CLi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Lithium phenylacetylide solution at a concentration of 1.0 M in THF. TSS does not represent this product as USP, BP, or EP grade.
How should Lithium phenylacetylide solution be handled?
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Lithium phenylacetylide solution is highly flammable and reacts with water, releasing flammable gases. It causes severe skin burns and eye damage. Handle with extreme care in a well-ventilated area, using appropriate personal protective equipment, including face shields, gloves, and respirators. Store under an inert atmosphere away from ignition sources and incompatible materials.
How is Lithium phenylacetylide solution packed and shipped?
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Lithium phenylacetylide solution is shipped as a hazardous material under UN 3399, Class 4.3, Packing Group II. TSS adheres to all regulations for secure and compliant packaging and export.
How can I request a sample or quote for Lithium phenylacetylide solution?
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To request a sample or a quote for Lithium phenylacetylide solution, please contact our sales department through the website or by phone, providing your specific requirements.
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