Leu-Leu-Leu
Trileucine (Leu-Leu-Leu) is a synthetic tripeptide with the chemical formula C18H35N3O4 and CAS number 10329-75-6. It functions as an endosome escape moiety, capable of pH-dependent endosomal membrane disruption to facilitate the release of intracellular agents, such as antisense oligonucleotides. Additionally, it serves as a valuable tool for assessing the absorption characteristics of reversed-phase liquid chromatography media.
- Synonyms
- Trileucine
Endosomal Escape Moiety
Trileucine can be employed to disrupt endosomal membranes in a pH-dependent manner, aiding the intracellular release of therapeutic agents like antisense oligonucleotides.
HPLC Media Evaluation
This tripeptide is utilised in the evaluation of absorption characteristics for various reversed-phase liquid chromatography (HPLC) media.
| Molecular weight | 357.49 |
|---|---|
| Empirical formula | C18H35N3O4 |
| Assay | ≥90% (elemental analysis) |
| Storage temperature | −20°C |
| Application | Trileucine (Leu-Leu-Leu), an endosome escape moiety, may be used for pH-dependent endosomal membrane disruption to release agents such as antisense oligonucleotides (AONs) inside cells. Trileucine is used to evaluate the absorption characteristics of reversed phase liquid chromatography (HPLC) media. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trileucine (Leu-Leu-Leu) used for?
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Trileucine is primarily used as an endosome escape moiety for pH-dependent endosomal membrane disruption to release agents like antisense oligonucleotides within cells. It is also used to evaluate the absorption characteristics of reversed-phase liquid chromatography (HPLC) media.
What is the CAS number and formula for Trileucine?
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The CAS number for Trileucine is 10329-75-6, and its empirical formula (Hill notation) is C18H35N3O4.
What is the purity or grade of Trileucine?
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This product is supplied with an assay of ≥90% as determined by elemental analysis. It is suitable for research and technical applications.
What are the safety considerations when handling Trileucine?
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When handling Trileucine, it is recommended to wear eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is advised. The WGK (German water hazard class) is 3.
How is Trileucine shipped and exported?
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Trileucine is typically shipped and exported under conditions suitable for maintaining its stability, often requiring storage at -20°C. TSS is a global supplier and exporter.
How can I request a quote for Trileucine?
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To request a quote for Trileucine, please contact our sales department via the website or direct email, specifying the quantity required.
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