Ketoconazole
Ketoconazole (CAS: 65277-42-1) is an antifungal agent with the molecular formula C26H28Cl2N4O4 and a molecular weight of 531.43. It functions as a CYP3A4 inhibitor. Available from Tech Serve Solutions with a purity of ≥98% by HPLC, this compound is supplied for research and laboratory applications. Ketoconazole is provided under stringent quality controls to meet the needs of scientific investigation.
- IUPAC
- (±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine
CYP3A4 Inhibition Studies
Ketoconazole serves as a potent inhibitor of the cytochrome P450 3A4 (CYP3A4) enzyme. It is utilised in biochemical research to investigate drug metabolism pathways and enzyme kinetics. Researchers employ Ketoconazole to understand its impact on the metabolism of various substrates.
Antifungal Research
As an imidazole antifungal, Ketoconazole is used in laboratory settings to study mechanisms of fungal growth inhibition. Its application aids in the development and testing of new antifungal therapies and understanding resistance mechanisms.
Drug Metabolism and Pharmacokinetics
Ketoconazole is widely used in pre-clinical research to explore drug-drug interactions and metabolic profiles. Its known inhibitory effects on CYP enzymes make it a valuable tool for assessing the pharmacokinetic behaviour of potential drug candidates.
| Molecular weight | 531.43 |
|---|---|
| Empirical formula | C26H28Cl2N4O4 |
| Assay | ≥98% (HPLC) |
| Colour | white to light yellow |
| Solubility | DMSO: soluble |
| Storage temperature | 2-8°C |
| Application | CYP3A4 inhibitor |
Hazard statements
- H301Toxic if swallowed
- H360F
- H373May cause damage to organs through prolonged exposure
- H410Very toxic to aquatic life with long-lasting effects
Precautionary statements
- P201Obtain special instructions before use
- P273Avoid release to the environment
- P301IF SWALLOWED
- P308IF exposed or concerned
- P501Dispose of contents and container per local regulations
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T,N |
| Risk statements (R) | 60-25-48/22-50/53 |
| Safety statements (S) | 53-45-60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ketoconazole primarily used for in research?
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In research, Ketoconazole is primarily utilised for its role as a CYP3A4 inhibitor and as an antifungal agent to study drug metabolism, enzyme kinetics, and antifungal efficacy.
What are the CAS number and molecular formula for Ketoconazole?
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The CAS number for Ketoconazole is 65277-42-1, and its molecular formula is C26H28Cl2N4O4.
What grade and purity does Tech Serve Solutions supply for Ketoconazole?
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Tech Serve Solutions supplies Ketoconazole with a minimum purity of 98% as determined by HPLC. We do not represent this product as USP, BP, EP, or pharmacopoeia grade unless explicitly stated in the product specifications.
How should Ketoconazole be handled safely?
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Ketoconazole is classified as toxic if swallowed, may damage fertility or the unborn child, can cause damage to organs through prolonged or repeated exposure, and is very toxic to aquatic life with long-lasting effects. Handling requires appropriate personal protective equipment, including eyeshields, face shields, gloves, and P2 respirator cartridges. Ensure adequate ventilation and avoid environmental release.
Is Ketoconazole a controlled substance?
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The provided data does not indicate that Ketoconazole is a controlled substance under standard regulations for chemical supply. However, users should always comply with local and national regulations regarding its procurement and use.
How is Ketoconazole shipped and exported?
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Ketoconazole is shipped and exported according to international regulations for hazardous materials, identified as UN 2811, Class 6.1, Packing Group III. Storage is recommended at 2-8°C.
How can I request a quote or sample of Ketoconazole?
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To request a quote or sample of Ketoconazole, please contact the Tech Serve Solutions sales team through our website or designated contact channels, providing your specific requirements and shipping details.
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