Isonipecotic acid
Isonipecotic acid (CAS 498-94-2, C6H11NO2, MW 129.16) is a heterocyclic compound utilized as a key building block in chemical synthesis. It is an important intermediate in the preparation of various pharmaceutical agents, including antibiotic derivatives, receptor agonists, and enzyme inhibitors. This compound is vital for researchers and manufacturers developing novel therapeutics targeting conditions such as cardiovascular disease, rheumatoid arthritis, and cancer.
- IUPAC
- 4-Piperidinecarboxylic acid,Hexahydroisonicotinic acid
- Synonyms
- 4-Piperidinecarboxylic acidHexahydroisonicotinic acid
Synthesis of Antibiotic Nitroxoline Derivatives
Isonipecotic acid serves as a reactant in the synthesis of nitroxoline derivatives, which have demonstrated potential for cathepsin B inhibition, an area of interest in drug discovery.
Development of Sphingosine-1-Phosphate Receptor Agonists
This compound is employed in the synthetic routes leading to sphingosine-1-phosphate receptor agonists, which are investigated for various therapeutic applications.
Preparation of RhoA Inhibitors
Isonipecotic acid is a precursor for RhoA inhibitors, which are being explored for their potential in treating cardiovascular diseases.
HDAC Inhibitor Synthesis
It is used in the preparation of alkyl piperidine and piperazine hydroxamic acids, a class of compounds investigated as HDAC inhibitors.
CHK1 and IKK2 Inhibitor Research
The molecule functions as a building block for CHK1 inhibitors and IKK2 inhibitors, with the latter being studied for rheumatoid arthritis treatment.
| Molecular weight | 129.16 |
|---|---|
| Empirical formula | C6H11NO2 |
| Assay | 97% |
| Application | Reactant for synthesis of:• Antibiotic nitroxoline derivatives for cathepsin B inhibition1• Sphingosine-1-phosphate receptor agonists2• RhoA inhibitors for cardiovascular disease therapy3• Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors• CHK1 inhibitors4• IKK2 inhibitors for investigations into rheumatoid arthritis treatment5 |
| Melting point | >300 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Isonipecotic acid used for?
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Isonipecotic acid is primarily used as a building block in chemical synthesis, particularly for the preparation of various pharmaceutical agents including antibiotic derivatives, receptor agonists, and enzyme inhibitors for cardiovascular disease, cancer, and rheumatoid arthritis research.
What are the CAS number and formula for Isonipecotic acid?
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The CAS number for Isonipecotic acid is 498-94-2 and its empirical formula is C6H11NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Isonipecotic acid with a purity of 97%. This product is supplied for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
How should I handle Isonipecotic acid?
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Isonipecotic acid is classified as a Warning (GHS07) substance. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, should be used. Ensure adequate ventilation.
Is Isonipecotic acid a controlled substance?
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The provided data does not indicate that Isonipecotic acid is a controlled substance.
How is Isonipecotic acid packed and shipped?
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Isonipecotic acid is carefully packed and exported by Tech Serve Solutions, adhering to international shipping regulations for chemical compounds.
How can I request a sample or quote for Isonipecotic acid?
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To request a sample or quote for Isonipecotic acid, please contact our sales department through the TSS website or your designated account manager.
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