Isoindoline
Isoindoline (CAS: 496-12-8), with the empirical formula C8H9N and a molecular weight of 119.16 g/mol, is a heterocyclic organic compound. It serves as a valuable building block in chemical synthesis, particularly for creating specialised catalysts. Its primary documented application involves its use in synthesising a chiral diamine catalyst derived from L-proline, which is employed in the asymmetric acylation of alcohols, demonstrating its utility in stereoselective organic chemistry.
Catalyst Synthesis
Isoindoline is used in the preparation of chiral diamine catalysts, specifically those derived from L-proline. These catalysts are crucial for facilitating the asymmetric acylation of alcohols, enabling stereoselective synthesis.
Asymmetric Acylation
The catalysts synthesised using isoindoline are employed in the asymmetric acylation of alcohols. This process is essential in organic chemistry for controlling the stereochemical outcome of reactions.
Heterocyclic Building Block
As a fundamental heterocyclic compound, isoindoline is a versatile building block in organic synthesis. It can be incorporated into more complex molecular structures for various research and development purposes.
| Molecular weight | 119.16 |
|---|---|
| Empirical formula | C8H9N |
| Assay | 97% |
| Boiling point | 221 °C(lit.) |
| Density | 1.05 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.57(lit.) |
| Storage temperature | 2-8°C |
| Melting point | 17 °C(lit.) |
| Application | Used to make a chiral diamine catalyst from L-proline for the asymmetric acylation of alcohols.1 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 94 °C / 201.2 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Isoindoline primarily used for?
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Isoindoline is primarily used as a building block in chemical synthesis, notably for preparing chiral diamine catalysts used in the asymmetric acylation of alcohols.
What is the CAS number and molecular formula for Isoindoline?
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The CAS number for Isoindoline is 496-12-8, and its empirical formula is C8H9N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Isoindoline with an assay of 97%. We do not represent this product as USP, BP, EP, or any pharmacopoeia grade.
How should Isoindoline be handled safely?
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Isoindoline is classified as a Warning substance, with hazards including skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection, should be used. Ensure adequate ventilation and avoid inhalation of vapours or dust.
How is Isoindoline packed and shipped by TSS?
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Tech Serve Solutions exports fine chemicals globally. Specific packing and shipping details for Isoindoline will be provided upon inquiry, adhering to all relevant international regulations.
How can I request a sample or quote for Isoindoline?
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To request a sample or a quotation for Isoindoline, please contact our sales team directly through our website or via the provided contact information.
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