Isobutyl chloroformate
Isobutyl chloroformate (CAS: 543-27-1) is a colourless liquid with a pungent odour. This reactive acid halide, with a molecular weight of 136.58, serves as a key intermediate in organic synthesis. Its primary applications lie in the preparation of carbonates, isocyanates, and other organic compounds, making it a valuable building block for pharmaceuticals and fine chemicals. Isobutyl chloroformate is supplied by TSS with an assay of 98%.
- IUPAC
- Chloroformic acid isobutyl ester,IBCF
- Synonyms
- Chloroformic acid isobutyl esterIBCF
Organic Synthesis Intermediate
Isobutyl chloroformate acts as a versatile acylating agent in organic synthesis. It is frequently used for introducing the isobutyloxycarbonyl protecting group in the synthesis of complex molecules, including pharmaceuticals and agrochemicals.
Preparation of Carbonates
This compound is employed in the synthesis of dialkyl carbonates and related structures. These reactions are foundational for creating various organic derivatives and functional materials.
Synthesis of Isocyanates
Isobutyl chloroformate can be utilized in the production of isocyanates, which are critical intermediates in the manufacture of polyurethanes and other polymers.
| Molecular weight | 136.58 |
|---|---|
| Linear formula | ClCO2CH2CH(CH3)2 |
| Assay | 98% |
| Boiling point | 128.8 °C(lit.) |
| Density | 1.053 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.407(lit.) |
| Solubility | benzene: misciblechloroform: misciblediethyl ether: miscible |
| Vapour pressure | 0.33 mmHg (20 °C) |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 36 °C / 96.8 °F |
| Transport (UN / ADR) | UN 3390 6.1/PG 1 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | T |
| Risk statements (R) | 10-22-23-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Isobutyl chloroformate used for?
+
Isobutyl chloroformate is primarily used as an intermediate in organic synthesis for preparing carbonates, isocyanates, and for introducing protecting groups in the synthesis of pharmaceuticals and fine chemicals.
What are the CAS number and formula for Isobutyl chloroformate?
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The CAS number for Isobutyl chloroformate is 543-27-1. Its linear formula is ClCO2CH2CH(CH3)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Isobutyl chloroformate with a purity of 98% (assay). This is a technical grade suitable for research and synthesis; TSS does not represent it as USP, BP, or EP grade.
How should Isobutyl chloroformate be handled safely?
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Isobutyl chloroformate is a flammable liquid and is toxic by inhalation, ingestion, and skin contact; it causes severe skin burns and eye damage. Handle with extreme caution in a well-ventilated area, wearing appropriate personal protective equipment including a faceshield, chemical-resistant gloves, and a suitable respirator. Refer to the Safety Data Sheet (SDS) for detailed handling procedures.
How is Isobutyl chloroformate packed and shipped?
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Isobutyl chloroformate is packed in compliance with international shipping regulations for hazardous materials, including UN 3390 classification. TSS exports globally, adhering to all necessary safety and transport requirements.
How can I request a sample or quote for Isobutyl chloroformate?
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To request a sample or a quote for Isobutyl chloroformate, please contact the TSS sales team via our website or direct contact details, providing your specific requirements.
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