Irinotecan hydrochloride
Irinotecan hydrochloride (CAS: 100286-90-6) is a semi-synthetic derivative of camptothecin. With the molecular formula C33H38N4O6 · HCl and a molecular weight of 623.14 g/mol, it functions as a potent inhibitor of topoisomerase I. This biochemical reagent is primarily utilised in biochemical research and as a tool for studying enzyme mechanisms and cellular processes.
- IUPAC
- (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester,CPT-11,[1,4′-Bipiperidine]-1′-carboxylic acid
Topoisomerase I Inhibition
Irinotecan hydrochloride is a well-established inhibitor of human topoisomerase I. Its mechanism involves stabilising the covalent complex formed between DNA and the enzyme, leading to DNA strand breaks and ultimately inhibiting DNA replication and transcription.
Biochemical Research
This compound serves as a valuable tool in biochemical and molecular biology research. It is used to investigate DNA repair pathways, cell cycle regulation, and the role of topoisomerase I in various cellular functions.
Enzyme Studies
As an enzyme inhibitor, Irinotecan hydrochloride is employed in studies focused on understanding enzyme kinetics, structure-activity relationships, and the development of novel therapeutic agents targeting topoisomerase I.
| Molecular weight | 623.14 |
|---|---|
| Empirical formula | C33H38N4O6 · HCl |
| Storage temperature | 2-8°C |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... TOP1(7150) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Irinotecan hydrochloride used for?
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Irinotecan hydrochloride is used in biochemical research as a potent inhibitor of topoisomerase I, aiding in the study of DNA replication, transcription, and repair pathways.
What are the CAS number and formula for Irinotecan hydrochloride?
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The CAS number for Irinotecan hydrochloride is 100286-90-6, and its molecular formula is C33H38N4O6 · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Irinotecan hydrochloride for research purposes. The specific assay and grade are detailed on the product page. We do not represent this product as USP, BP, or EP grade unless explicitly stated in the specifications.
How should Irinotecan hydrochloride be handled?
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Irinotecan hydrochloride is classified as harmful if swallowed (H302). Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Avoid dust formation and inhalation.
Is Irinotecan hydrochloride a controlled substance?
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The provided data does not indicate that Irinotecan hydrochloride is a controlled substance.
How is Irinotecan hydrochloride packaged, shipped, and exported?
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Irinotecan hydrochloride is carefully packaged to ensure stability during transit. Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals, adhering to all relevant shipping regulations.
How can I request a sample or quote for Irinotecan hydrochloride?
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To request a sample or a quote for Irinotecan hydrochloride, please use the contact form on our website or contact our sales department directly.
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