Hexyllithium solution
Hexyllithium solution (CAS: 21369-64-2, Formula: CH₃(CH₂)₅Li, MW: 92.11) is a highly reactive organometallic reagent and a strong base. Supplied as a 2.3 M solution in hexane, it is a critical tool in organic synthesis. Its potent nucleophilic character makes it invaluable for carbon-carbon bond formation, deprotonation reactions, and as an initiator in polymerisation processes. Its pyrophoric nature demands careful handling and storage under inert conditions.
Organometallic Synthesis
Hexyllithium is a powerful nucleophile used extensively for the formation of carbon-carbon bonds in the synthesis of complex organic molecules and pharmaceuticals. It readily reacts with electrophiles such as alkyl halides and carbonyl compounds.
Deprotonation Reactions
As a very strong base, hexylithium is employed for the deprotonation of weakly acidic C-H bonds, generating carbanions that can then participate in further synthetic transformations. This is common in the synthesis of functionalised aromatic and aliphatic compounds.
Polymerisation Initiation
Organolithium compounds, including hexylithium, can serve as initiators in anionic polymerisation reactions. This allows for the controlled synthesis of polymers with specific molecular weights and architectures.
| Molecular weight | 92.11 |
|---|---|
| Linear formula | CH3(CH2)5Li |
| Boiling point | 69 °C |
| Density | 0.708 g/mL at 25 °C |
| Concentration | 2.3 M in hexane |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H250Catches fire spontaneously if exposed to air
- H260In contact with water releases flammable gases
- H304May be fatal if swallowed and enters airways
- H314Causes severe skin burns and eye damage
- H336May cause drowsiness or dizziness
- H361F
- H373May cause damage to organs through prolonged exposure
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P222Do not allow contact with air
- P223Do not allow contact with water
- P231Handle under inert gas
- P370In case of fire
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -9 °C / 15.8 °F |
| Transport (UN / ADR) | UN 3394 4.2/PG 1 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | F,C,N |
| Risk statements (R) | 11-14/15-17-35-48/20-51/53-62-65-67 |
| Safety statements (S) | 26-36/37/39-43-45-61-62 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Hexyllithium solution used for?
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Hexyllithium solution is a versatile organometallic reagent and strong base used in organic synthesis primarily for carbon-carbon bond formation, deprotonation of acidic C-H bonds, and as an initiator in anionic polymerisation.
What is the CAS number and formula for Hexyllithium solution?
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The CAS number for Hexyllithium solution is 21369-64-2, and its chemical formula is CH₃(CH₂)₅Li.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Hexyllithium solution at a concentration of 2.3 M in hexane. We do not represent this product as USP, BP, or EP grade, and it should be considered for research and technical applications.
How should Hexyllithium solution be handled and stored?
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Hexyllithium solution is pyrophoric and reacts violently with water. It must be handled under an inert atmosphere (e.g., nitrogen or argon) and stored at 2-8°C. Appropriate personal protective equipment, including flame-retardant clothing, gloves, and eye protection, is essential due to its extreme reactivity and flammability.
How is Hexyllithium solution packed, shipped, and exported?
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Hexyllithium solution is supplied in specialised Sure/Seal™ bottles designed for safe handling of air- and moisture-sensitive reagents. We adhere to strict international regulations for the transport of hazardous chemicals, ensuring secure packing and export.
How can I request a sample or quote for Hexyllithium solution?
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To request a sample or obtain a quotation for Hexyllithium solution, please contact our sales team via the website or direct email, providing your specific requirements and delivery location.
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