Hexanoic anhydride
Hexanoic anhydride (CAS 2051-49-2), with the linear formula [CH3(CH2)4CO]2O, is a carboxylic acid anhydride with a molecular weight of 214.30 g/mol. This compound serves as a key reagent in organic synthesis. It is particularly valuable for the preparation of ester prodrugs, the modification of polymers like chitosan for nanoparticle and surfactant applications, and other acylation reactions in chemical synthesis.
- IUPAC
- Caproic anhydride
- Synonyms
- Hexanoyl anhydrideCaproic anhydride
![Hexanoic anhydride ([CH3(CH2)4CO]2O) — chemical structure, CAS 2051-49-2; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F2051-49-2.png&w=3840&q=75)
Green Synthesis of Acyclovir Prodrugs
Hexanoic anhydride facilitates the green synthesis of esters of acyclovir, which are important prodrugs. This application highlights its utility in developing more effective pharmaceutical agents through efficient chemical processes.
Chitosan Nanoparticle Preparation
The compound is employed in the preparation of hexanoyl-modified chitosan nanoparticles. This modification enhances the properties of chitosan for various biomedical and drug delivery applications.
Chitosan-Based Polymeric Surfactants
Hexanoic anhydride is used for the N-acylation of chitosans, leading to the creation of chitosan-based polymeric surfactants. These surfactants find use in diverse formulations and industrial processes.
General Acylation Reagent
As a reactive anhydride, hexanoic anhydride is a versatile building block for introducing the hexanoyl group into various organic molecules, supporting a wide range of chemical synthesis endeavours.
| Molecular weight | 214.30 |
|---|---|
| Linear formula | [CH3(CH2)4CO]2O |
| Assay | 97% |
| Grade | purum |
| Boiling point | 246-248 °C(lit.) |
| Density | 0.928 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.428(lit.) |
| Application | Hexanoic anhydride has been used in:• green synthesis of esters of acyclovir (acyclovir prodrugs)1• preparation of hexanoyl-modified chitosan nanoparticles2 and chitosan-based polymeric surfactants via N-acylation of chitosans3 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Hexanoic anhydride used for?
+
Hexanoic anhydride is used in organic synthesis, including the green synthesis of acyclovir prodrugs and the preparation of hexanoyl-modified chitosan nanoparticles and surfactants.
What is the CAS number and formula for Hexanoic anhydride?
+
The CAS number for Hexanoic anhydride is 2051-49-2, and its linear formula is [CH3(CH2)4CO]2O.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Hexanoic anhydride in purum grade with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should Hexanoic anhydride be handled safely?
+
Hexanoic anhydride is classified as dangerous and causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment, including gloves, goggles, and a facesheild. Ensure adequate ventilation. In case of contact, rinse immediately and thoroughly with water.
How is Hexanoic anhydride packed and shipped?
+
Hexanoic anhydride is packed according to industry standards for hazardous materials and is exported globally by Tech Serve Solutions, adhering to all relevant transportation regulations.
How can I request a quote or sample for Hexanoic anhydride?
+
To request a quote or sample for Hexanoic anhydride, please contact our sales department via the website or by phone. Our team will be pleased to assist you.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis